Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-Y693-STAT4 [nucleoplasm]
Stable Identifier
R-HSA-8950636
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of ADP-ribosylation factor 1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of BolA-like protein 2 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Carbonic anhydrase 1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Cofilin-1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Glutathione S-transferase omega-1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Heterogeneous nuclear ribonucleoprotein D-like (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Heterogeneous nuclear ribonucleoproteins A2/B1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of IFNG gene (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Interleukin-10 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Lamin-B1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Macrophage migration inhibitory factor (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Moesin (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of PAK2 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Peptidyl-prolyl cis-trans isomerase A (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Phosphatidylinositol transfer protein alpha isoform (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Plasminogen activator inhibitor 2 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Programmed cell death protein 4 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Proteasome activator complex subunit 2 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Ras-related protein Ral-A (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Ras-related protein Rap-1b (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of SOD1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of Stress-70 protein, mitochondrial (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of TCP1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of annexin A2 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of calponin-2 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of cell division cycle 42 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of glutathione S-transferase alpha 2 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of heterogeneous nuclear ribonucleoprotein F (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of lymphocyte cytosolic protein 1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of ribosomal protein lateral stalk subunit P0 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of superoxide dismutase 2 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Expression of transaldolase 1 (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Y693-STAT4 dimer translocates to the nucleus (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Homo sapiens)
p-Y705-STAT3:p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
EBI3 gene transcription and translation (Homo sapiens)
p-Y693-STAT4:p-Y701-STAT1:EBI3 gene [nucleoplasm] (Homo sapiens)
p-Y693-STAT4:p-Y701-STAT1 [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
IL12A gene transcription and translation (Homo sapiens)
p-Y693-STAT4:p-Y701-STAT1:IL12A gene [nucleoplasm] (Homo sapiens)
p-Y693-STAT4:p-Y701-STAT1 [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
p-STAT1:p-STAT4 translocates to the nucleus (Homo sapiens)
p-Y693-STAT4:p-Y701-STAT1 [nucleoplasm] (Homo sapiens)
p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
9890938
Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling
Hoey, T
,
McKinney, J
,
Salvekar, A
,
Naeger, LK
J. Biol. Chem.
1999
External Reference Information
External Reference
UniProt:Q14765 STAT4
Gene Names
STAT4
Chain
chain:1-748
Reference Genes
BioGPS Gene:6775 STAT4
COSMIC (genes):STAT4 STAT4
CTD Gene:6775 STAT4
dbSNP Gene:6775 STAT4
ENSEMBL:ENSG00000138378 STAT4
ENSEMBL_homo_sapiens_GENE:ENSG00000138378.19 STAT4
HGNC:11365 STAT4
KEGG Gene (Homo sapiens):6775 STAT4
Monarch:6775 STAT4
NCBI Gene:6775 STAT4
OMIM:600558 STAT4
UCSC:Q14765 STAT4
Reference Transcript
RefSeq:NM_001243835.1 STAT4
RefSeq:XM_011511705.2 STAT4
RefSeq:NM_003151.3 STAT4
RefSeq:XM_006712719.3 STAT4
Other Identifiers
11733215_a_at
11749512_a_at
16906571
206118_PM_at
206118_at
2592358
2592359
2592362
2592365
2592366
2592367
2592368
2592369
2592370
2592371
2592373
2592376
2592378
2592379
2592380
2592381
2592383
2592384
2592386
2592387
2592389
2592397
2592398
2592399
2592401
2592402
2592403
2592404
2592405
6775
8057771
906_at
A_23_P305198
A_23_P68031
GE57803
GO:0000785
GO:0000978
GO:0000981
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006952
GO:0007165
GO:0007166
GO:0007259
GO:0019221
GO:0023052
GO:0030154
GO:0035722
GO:0042127
GO:0042802
GO:0043226
GO:0043434
GO:0045063
GO:0045944
GO:0048856
GO:0071310
GO:0090575
GO:0140110
HMNXSV003019127
ILMN_1785202
L78440_at
PH_hs_0004637
TC02002625.hg
g4507254_3p_at
Participates
as a component of
p-Y705-STAT3:p-Y693-STAT4 [nucleoplasm] (Homo sapiens)
p-Y693-STAT4:p-Y701-STAT1 [nucleoplasm] (Homo sapiens)
Y963-STAT4 dimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-STAT4 [cytosol]
p-Y693-STAT4 [cytosol]
STAT4 [cytosol]
Inferred To
phospho-dstC [nucleoplasm]
(Dictyostelium discoideum)
phospho-sta-2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-STAT4 [nucleoplasm]
(Bos taurus)
phospho-STAT4 [nucleoplasm]
(Canis familiaris)
phospho-STAT4 [nucleoplasm]
(Gallus gallus)
phospho-STAT4 [nucleoplasm]
(Sus scrofa)
phospho-Stat92E [nucleoplasm]
(Drosophila melanogaster)
phospho-stat4 [nucleoplasm]
(Xenopus tropicalis)
phospho-dstB [nucleoplasm]
(Dictyostelium discoideum)
phospho-Stat4 [nucleoplasm]
(Mus musculus)
phospho-sta-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-dstD [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-Y693-STAT4 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-Y693-STAT4 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of p-Y693-STAT4 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of p-Y693-STAT4 [nucleoplasm]
(Dictyostelium discoideum)
phospho-dstA [nucleoplasm]
(Dictyostelium discoideum)
Modified Residues
Name
O4'-phospho-L-tyrosine at 693
Coordinate
693
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_003142.1
,
NP_001230764.1
,
XP_011510007.1
,
XP_006712782.1
OpenTargets
ENSG00000138378
GeneCards
Q14765
HPA
ENSG00000138378-STAT4
Ensembl
ENSG00000138378
,
ENSP00000376134
,
ENSP00000351255
,
ENST00000358470
,
ENST00000392320
PRO
Q14765
Pharos - Targets
Q14765
Orphanet
21733
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14765 STAT4
4
p-Y693-STAT4 [nucleoplasm]
(R-HSA-8950636)
p-STAT4 [cytosol]
(R-HSA-8950350)
p-Y693-STAT4 [cytosol]
(R-HSA-8950343)
STAT4 [cytosol]
(R-HSA-8950606)
0.558
2
UniProt:Q9BVL2 NUP58
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
STAT1 [cytosol]
(R-HSA-629622)
0.536
2
UniProt:Q99665 IL12RB2
2
p-Y800-IL12RB2 [plasma membrane]
(R-HSA-8950376)
IL12RB2 [plasma membrane]
(R-HSA-447249)
0.527
2
IntAct:EBI-10952519 STAT
0.499
5
UniProt:O14796 SH2D1B
1
SH2D1B [cytosol]
(R-HSA-5685187)
0.488
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.488
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text