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CRLF1 [cytosol]
Stable Identifier
R-HSA-8950296
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
CRLF1:IL27 translocates to the extracellular region (Homo sapiens)
CRLF1:IL27 [cytosol] (Homo sapiens)
CRLF1 [cytosol] (Homo sapiens)
IL27 binds CRLF1 (Homo sapiens)
CRLF1 [cytosol] (Homo sapiens)
CRLF1:IL27 [cytosol] (Homo sapiens)
CRLF1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23904441
Modulation of inflammation by interleukin-27
Bosmann, M
,
Ward, PA
J. Leukoc. Biol.
2013
External Reference Information
External Reference
UniProt:O75462 CRLF1
Gene Names
CRLF1, UNQ288/PRO327
Chain
signal peptide:1-37, chain:38-422
Reference Genes
BioGPS Gene:9244 CRLF1
COSMIC (genes):CRLF1 CRLF1
CTD Gene:9244 CRLF1
dbSNP Gene:9244 CRLF1
ENSEMBL:ENSG00000006016 CRLF1
HGNC:2364 CRLF1
KEGG:hsa:9244 CRLF1
Monarch:9244 CRLF1
NCBI Gene:9244 CRLF1
OMIM:604237 CRLF1
UCSC:O75462 CRLF1
Reference Transcript
RefSeq:NM_004750.5 CRLF1
Participates
as a component of
CRLF1:IL27 [cytosol] (Homo sapiens)
as an input of
IL27 binds CRLF1 (Homo sapiens)
Other forms of this molecule
CRLF1 [extracellular region]
Inferred To
Crlf1 [cytosol]
(Mus musculus)
Crlf1 [cytosol]
(Rattus norvegicus)
CRLF1 [cytosol]
(Bos taurus)
CRLF1 [cytosol]
(Canis familiaris)
CRLF1 [cytosol]
(Gallus gallus)
CRLF1 [cytosol]
(Sus scrofa)
crlf1a [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_004741.1
ENSEMBL
ENSG00000006016
,
ENSP00000376188
,
ENST00000392386
OpenTargets
ENSG00000006016
GeneCards
CRLF1
HPA
ENSG00000006016-CRLF1
PRO
O75462
Pharos - Targets
O75462
GlyGen
O75462
Orphanet
CRLF1
PDB
8D7H
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26992 CNTFR
1
CNTFR [plasma membrane]
(R-HSA-5696438)
0.609
2
UniProt:Q9UBD9 CLCF1
1
CLCF1 [extracellular region]
(R-HSA-5693175)
0.589
4
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.544
3
UniProt:Q9UK22 FBXO2
1
FBXO2 [cytosol]
(R-HSA-976044)
0.527
3
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