PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)

Stable Identifier
R-HSA-8949649
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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The mitochondrial endopeptidase PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) yielding SMDT1 (Konig et al. 2016). Mature SMDT1 is assembled into the MCU complex where it serves to bridge the MCU pore and the MCU regulators MICU1 and MICU2 (or MICU3 in neurons).

Literature References
PubMed ID Title Journal Year
27642048 The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

König, T, Tröder, SE, Bakka, K, Korwitz, A, Richter-Dennerlein, R, Lampe, PA, Patron, M, Mühlmeister, M, Guerrero-Castillo, S, Brandt, U, Decker, T, Lauria, I, Paggio, A, Rizzuto, R, Rugarli, EI, De Stefani, D, Langer, T

Mol. Cell 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of Mitochondrial processing peptidase [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Target Pathogen
Authored
Reviewed
Created