PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)

Stable Identifier
R-HSA-8949649
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
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PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)
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The mitochondrial endopeptidase PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) yielding SMDT1 (Konig et al. 2016). Mature SMDT1 is assembled into the MCU complex where it serves to bridge the MCU pore and the MCU regulators MICU1 and MICU2 (or MICU3 in neurons).
Literature References
PubMed ID Title Journal Year
27642048 The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

Bakka, K, König, T, Rizzuto, R, Guerrero-Castillo, S, Korwitz, A, Brandt, U, Langer, T, De Stefani, D, Tröder, SE, Lampe, PA, Rugarli, EI, Decker, T, Richter-Dennerlein, R, Lauria, I, Paggio, A, Mühlmeister, M, Patron, M

Mol. Cell 2016
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of Mitochondrial processing peptidase [mitochondrial matrix]

Physical Entity
Mitochondrial processing peptidase [mitochondrial matrix] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Bos taurus)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Caenorhabditis elegans)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Canis familiaris)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Drosophila melanogaster)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Gallus gallus)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Mus musculus)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Rattus norvegicus)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Sus scrofa)
Authored
May, B  (2016-11-28)
Reviewed
Drago, I  (2017-01-21)
Created
May, B  (2016-11-28)
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