Reactome | SMDT1 [mitochondrial inner membrane]

SMDT1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949227

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

fullName evidence="8"Essential MCU regulator, mitochondrial, EMRE_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H4I9 SMDT1

Gene Names

SMDT1, C22orf32, EMRE

Chain

transit peptide:1-52, chain:53-107

Reference Genes

BioGPS Gene:91689 SMDT1

COSMIC (genes):SMDT1 SMDT1

CTD Gene:91689 SMDT1

dbSNP Gene:91689 SMDT1

ENSEMBL:ENSG00000183172 SMDT1

ENSEMBL:ENSG00000183172.9 SMDT1

ENSEMBL:ENSG00000272835.3 SMDT1

ENSEMBL:ENSG00000272901.5 SMDT1

ENSEMBL:ENSG00000274112.2 SMDT1

HGNC:25055 SMDT1

KEGG Gene (Homo sapiens):91689 SMDT1

Monarch:91689 SMDT1

NCBI Gene:91689 SMDT1

OMIM:615588 SMDT1

UCSC:Q9H4I9 SMDT1

Reference Transcript

Other Identifiers

11729147_a_at

11729148_a_at

16930860

225794_PM_s_at

225794_s_at

225795_PM_at

225795_at

3947311

3947312

3947313

3947314

3947316

3947318

3947319

3947320

3947321

57173_at

77862_at

8073578

91689

A_23_P211584

A_24_P271542

GE83641

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005759

GO:0006811

GO:0006816

GO:0006851

GO:0016020

GO:0036444

GO:0043226

GO:0051560

GO:0055065

GO:0055085

GO:1990246

HMNXSV003018518

Hs.306083.0.S1_3p_a_at

ILMN_1706859

PH_hs_0015719

TC22001473.hg

Participates

as an input of

as an output of

PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)

as a component of

MCU complex [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

SMDT1 transit peptide [mitochondrial matrix]

proSMDT1 [mitochondrial inner membrane]

Inferred To

Smdt1 [mitochondrial inner membrane] (Mus musculus)

emre-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

EMRE [mitochondrial inner membrane] (Drosophila melanogaster)

si:ch211-133l11.4 [mitochondrial inner membrane] (Danio rerio)

Ghost homologue of SMDT1 [mitochondrial inner membrane] (Dictyostelium discoideum)

Ghost homologue of SMDT1 [mitochondrial inner membrane] (Xenopus tropicalis)

SMDT1 [mitochondrial inner membrane] (Bos taurus)

SMDT1 [mitochondrial inner membrane] (Canis familiaris)

SMDT1 [mitochondrial inner membrane] (Gallus gallus)

SMDT1 [mitochondrial inner membrane] (Rattus norvegicus)

SMDT1 [mitochondrial inner membrane] (Sus scrofa)

Cross References

RefSeq

NP_201575.3, XP_011528811.1

OpenTargets

ENSG00000183172

HPA

ENSG00000183172-SMDT1

GeneCards

Q9H4I9

Ensembl

ENSP00000485029, ENSG00000274112, ENST00000607293, ENSG00000272835, ENSG00000272901, ENST00000331479, ENSG00000183172, ENSP00000327467, ENST00000615504, ENST00000571525, ENSP00000459368, ENSP00000475471

PRO

Q9H4I9

Pharos - Targets

Q9H4I9

PDB

6XJX, 6XJV, 6O58, 6WDO, 6WDN, 6K7X, 6K7Y, 6O5B

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NE86 MCU	1	MCU [mitochondrial inner membrane] (R-HSA-8949184)	0.693	8
UniProt:Q9BPX6 MICU1	1	MICU1 [mitochondrial inner membrane] (R-HSA-8949180)	0.488	3
UniProt:Q8IYU8 MICU2	1	MICU2 [mitochondrial inner membrane] (R-HSA-8949166)	0.488	3

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