RUNX3:CBFB binds the RORC gene promoter

Stable Identifier
R-HSA-8949276
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX3:CBFB binds the RORC gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mice, the complex of RUNX3 and CBFB binds the promoter of the RORC (RORgamma) gene, encoding nuclear retinoid-related orphan receptor-gamma. The RUNX binding site TGTGGT is conserved between mouse and human RORC promoters. Mouse Runx3 is expressed in innate lymphoid cell lineages ILC1 and ILC3, but not ILC2 (Ebihara et al. 2015).
Literature References
PubMed ID Title Journal Year
26414766 Runx3 specifies lineage commitment of innate lymphoid cells

Stappenbeck, TS, Yang, L, Egawa, T, Yokoyama, WM, Ebihara, T, Groner, Y, Plougastel-Douglas, B, Bern, MD, Song, C, Colonna, M, Ryu, SH, Levanon, D

Nat. Immunol. 2015
Participants
Input
Output
Participates
as an event of
Inferred From
Runx3:Cbfb binds the Rorc gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-11-21)
Cite Us!