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RUNX3:CBFB [nucleoplasm]
Stable Identifier
R-HSA-8865463
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 Regulates Immune Response and Cell Migration (Homo sapiens)
ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:ITGAL gene,(ITGA4 gene) [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RORC gene expression is stimulated by RUNX3:CBFB (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:RORC gene [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:ITGAL gene,(ITGA4 gene) [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB binds the RORC gene promoter (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:RORC gene [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
SPP1 gene expression is stimulated by RUNX3 (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3 regulates BCL2L11 (BIM) transcription (Homo sapiens)
BCL2L11 (BIM) gene transcription is stimulated by RUNX3 (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3 regulates RUNX1-mediated transcription (Homo sapiens)
RUNX1 gene expression is inhibited by RUNX3 (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:RUNX1 gene [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3 binds the RUNX1 promoter (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:RUNX1 gene [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3 regulates WNT signaling (Homo sapiens)
CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3 regulates YAP1-mediated transcription (Homo sapiens)
TEADs:YAP1 binds CTGF gene (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3 regulates p14-ARF (Homo sapiens)
EP300 acetylates RUNX3 (Homo sapiens)
RUNX3:CBFB:EP300 [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
HDAC4 deacetylates RUNX3 (Homo sapiens)
RUNX3:CBFB:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3 binds EP300 (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:EP300 [nucleoplasm] (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
CBFB binds RUNX3 (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Binding of TCF/LEF:CTNNB1 to target gene promoters (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)
RUNX3:CBFB [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23333304
CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression
Hartley, PD
,
Mann, S
,
Gross, JD
,
Krogan, NJ
,
Kim, DY
,
Crosby, DC
,
Kwon, E
Mol. Cell
2013
Participants
components
CBFB [nucleoplasm]
(Homo sapiens)
RUNX3 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
RUNX3:CBFB:RUNX1 gene [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:EP300 [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:ITGAL gene,(ITGA4 gene) [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:RORC gene [nucleoplasm] (Homo sapiens)
as an input of
RUNX3 binds the RUNX1 promoter (Homo sapiens)
RUNX3 binds EP300 (Homo sapiens)
RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter (Homo sapiens)
RUNX3:CBFB binds the RORC gene promoter (Homo sapiens)
as an output of
CBFB binds RUNX3 (Homo sapiens)
This entity regulates
Positively
SPP1 gene expression is stimulated by RUNX3
(Homo sapiens)
Inferred To
RUNX3:CBFB [nucleoplasm]
(Bos taurus)
RUNX3:CBFB [nucleoplasm]
(Caenorhabditis elegans)
RUNX3:CBFB [nucleoplasm]
(Canis familiaris)
RUNX3:CBFB [nucleoplasm]
(Drosophila melanogaster)
RUNX3:CBFB [nucleoplasm]
(Gallus gallus)
RUNX3:CBFB [nucleoplasm]
(Mus musculus)
RUNX3:CBFB [nucleoplasm]
(Rattus norvegicus)
RUNX3:CBFB [nucleoplasm]
(Sus scrofa)
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