K63polyUb-IRAK1 dissociates

Stable Identifier
R-HSA-8948066
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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K63polyUb-IRAK1 dissociates
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Pellino1, 2 and possibly 3 are believed to directly catalyse polyubiquitylation of IRAK1 (Xiao et al. 2008; Butler et al. 2007; Ordureau et al. 2008). Following ubiquitination IRAK1 dissociates.

Literature References
PubMed ID Title Journal Year
17997719 The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1

Peggie, M, Ordureau, A, Carrick, E, Morrice, N, Windheim, M, Smith, H, Cohen, P

Biochem J 2008
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Orthologous Events
K63polyUb-IRAK1 dissociates (Caenorhabditis elegans)
K63polyUb-IRAK1 dissociates (Canis familiaris)
K63polyUb-IRAK1 dissociates (Danio rerio)
K63polyUb-IRAK1 dissociates (Drosophila melanogaster)
K63polyUb-IRAK1 dissociates (Mus musculus)
K63polyUb-IRAK1 dissociates (Rattus norvegicus)
K63polyUb-IRAK1 dissociates (Sus scrofa)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-09-06)
Created
Jupe, S  (2016-11-10)
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