K63polyUb-IRAK1 dissociates

Stable Identifier
R-HSA-8948066
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Pellino1, 2 and possibly 3 are believed to directly catalyse polyubiquitylation of IRAK1 (Xiao et al. 2008; Butler et al. 2007; Ordureau et al. 2008). Following ubiquitination IRAK1 dissociates.

Literature References
PubMed ID Title Journal Year
17997719 The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1

Ordureau, A, Smith, H, Windheim, M, Peggie, M, Carrick, E, Morrice, N, Cohen, P

Biochem J 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created