Pellino1, 2 and possibly 3 are believed to directly catalyse polyubiquitylation of IRAK1 (Xiao et al. 2008; Butler et al. 2007; Ordureau et al. 2008). Following ubiquitination IRAK1 dissociates.
Ordureau, A, Smith, H, Windheim, M, Peggie, M, Carrick, E, Morrice, N, Cohen, P
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