Reactome | p-T69,T71-ATF2 binds PTEN gene promoter

p-T69,T71-ATF2 binds PTEN gene promoter

Stable Identifier

R-HSA-8944397

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The transcription factor ATF2, activated downstream of stress signaling by p38 MAPKs, binds to ATF response elements in the PTEN gene promoter to activate PTEN transcription. It has not been examined whether ATF2 heterodimerization partners are involved in ATF2-mediated up-regulation of PTEN (Shen et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16418168	Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells Wang, J, Shen, YH, LeMaire, SA, Wang, XL, Coselli, JS, Gan, Y, Zhang, L, Wang, X	J. Biol. Chem.	2006

Participants

Input

Output

p-T69,T71-ATF2:PTEN gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

Regulation of PTEN gene transcription (Homo sapiens)

Authored

Salmena, L (2016-08-11)

Carracedo, A (2016-08-11)

Orlic-Milacic, M (2016-11-03)

Created

Orlic-Milacic, M (2016-11-03)

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