TCF/LEF:CTNNB1 bind canonical WNT target promoters

Stable Identifier
R-HSA-8944362
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TCF/LEF:CTNNB1 bind canonical WNT target promoters
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Transcription of canonical WNT target genes depends on the formation of a TCF/LEF:CTNNB1 complex at the WNT-responsive element (WRE) of the promoter (reviewed in Saito-Diaz et al, 2013). The ability of the TCF/LEF:beta-catenin complex to bind DNA is negatively regulated by NLK-dependent phosphorylation (Ishitani et al, 2003b). WNT targets AXIN2, DKK1, c-MYC and CCND1 all show decreased expression in A549 cells treated with shRNAs against NLK (Lv et al, 2013).
Literature References
PubMed ID Title Journal Year
12556497 Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling

Ishitani, T, Matsumoto, K, Ninomiya-Tsuji, J

Mol. Cell. Biol. 2003
23256519 The way Wnt works: Components and mechanism

Wang, X, Wallace, HA, Page-McCaw, A, Lee, E, Thorne, CA, Chen, TW, Saito-Diaz, K

Growth Factors 2013
23904219 Nemo-like kinase (NLK) inhibits the progression of NSCLC via negatively modulating Wnt signaling pathway

Liu, Y, Wan, C, Cong, X, Liu, Y, Mao, G, Lv, L, Xue, Q, Yang, Y, Ni, T, Li, M, Chen, B

J. Cell. Biochem. 2013
Participants
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Output
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as an event of
This event is regulated
Negatively by
Regulator
pT298-NLK dimer [nucleoplasm] (Homo sapiens)
Authored
Rothfels, K  (2016-11-03)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2016-11-03)
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