Transcription of canonical WNT target genes depends on the formation of a TCF/LEF:CTNNB1 complex at the WNT-responsive element (WRE) of the promoter (reviewed in Saito-Diaz et al, 2013). The ability of the TCF/LEF:beta-catenin complex to bind DNA is negatively regulated by NLK-dependent phosphorylation (Ishitani et al, 2003b). WNT targets AXIN2, DKK1, c-MYC and CCND1 all show decreased expression in A549 cells treated with shRNAs against NLK (Lv et al, 2013).
Ishitani, T, Matsumoto, K, Ninomiya-Tsuji, J
Wang, X, Wallace, HA, Page-McCaw, A, Lee, E, Thorne, CA, Chen, TW, Saito-Diaz, K
Liu, Y, Wan, C, Cong, X, Liu, Y, Mao, G, Lv, L, Xue, Q, Yang, Y, Ni, T, Li, M, Chen, B
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