SNAI1,SNAI2 bind the PTEN gene promoter

Stable Identifier
R-HSA-8944026
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SNAI1,SNAI2 bind the PTEN gene promoter
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The transcriptional repressor SNAI1 (Snail1) binds the promoter of the PTEN gene. Binding of SNAI1 to the PTEN promoter increases in response to ionizing radiation and interferes with binding of TP53 to the PTEN promoter. Phosphorylation of SNAI1 at serine residue S246 may be required for SNAI1-mediated repression of PTEN transcription (Escriva et al. 2008). Another Slug/Snail family member SNAI2 (SLUG) can also bind to the PTEN gene promoter to repress PTEN transcription (Uygur et al. 2015).
Literature References
PubMed ID Title Journal Year
25728608 SLUG is a direct transcriptional repressor of PTEN tumor suppressor

Liaw, L, Leikina, E, Wu, WS, Vary, C, Abramo, K, Uygur, B

Prostate 2015
18172008 Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis

Gridley, T, Murray, SA, García de Herreros, A, Herranz, N, Dave, N, Virtanen, I, Peiró, S, Montserrat-Sentís, B, Escrivà, M, Villagrasa, P, Francí, C

Mol. Cell. Biol. 2008
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Authored
Salmena, L  (2016-08-11)
Carracedo, A  (2016-08-11)
Orlic-Milacic, M  (2016-11-01)
Created
Orlic-Milacic, M  (2016-11-01)
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