TWIST1 binds the RUNX2 gene promoter

Stable Identifier
R-HSA-8940032
Type
Reaction [binding]
Species
Homo sapiens
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TWIST1 transcription factor binds the proximal P2 promoter of RUNX2. Binding involves the basic helix-loop-helix (bHLH) domain of TWIST1 and E1-box in the P2 promoter of RUNX2 (Yang et al. 2011). TWIST1, a transcriptional target of HIF1A (Yang et al. 2008) and STAT3 (Zhang et al. 2015), induces epithelial-to-mesenchymal transition (EMT) and promotes cancer metastasis (Yang et al. 2004). In zebrafish, Twist-mediated transactivation of runx2 controls skeletal development and dorsoventral patterning (Yang et al. 2011). Twist proteins also interact with the DNA-binding domain of RUNX2 to modulate its activity during skeletogenesis (Bialek et al. 2004).

Literature References
PubMed ID Title Journal Year
21931630 Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST

Yang, DC, Yang, MH, Tsai, CC, Huang, TF, Chen, YH, Hung, SC

PLoS ONE 2011
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