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RUNX2:CBFB binds the ITGBL1 gene promoter
Stable Identifier
R-HSA-8939833
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates genes involved in cell migration (Homo sapiens)
RUNX2:CBFB binds the ITGBL1 gene promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RUNX2, presumably associated with CBFB, binds to RUNX2 binding sites in the promoter of the ITGBL1 gene, encoding Integrin beta-like protein 1 (Li et al. 2015).
Literature References
PubMed ID
Title
Journal
Year
26060017
ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway
Li, XQ
,
Feng, YM
,
Liu, PF
,
Kong, PZ
,
Sun, Y
,
Li, DM
,
Wang, QS
,
Du, X
Cancer Res.
2015
Participants
Input
ITGBL1 gene [nucleoplasm]
(Homo sapiens)
RUNX2:CBFB [nucleoplasm]
(Homo sapiens)
Output
RUNX2:CBFB:ITGBL1 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RUNX2 regulates genes involved in cell migration (Homo sapiens)
Authored
Orlic-Milacic, M (2016-09-21)
Reviewed
Ducy, P (2017-08-04)
Created
Orlic-Milacic, M (2016-09-21)
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