RUNX2:CBFB binds the ITGA5 gene promoter

Stable Identifier
R-HSA-8939670
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX2:CBFB binds the ITGA5 gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RUNX2, presumably associated with CBFB, binds to OSE2 (osteoblast-specific cis-acting element 2) sites in the promoter of the ITGA5 gene, encoding Integrin alpha-5 (Li et al. 2016).
Literature References
PubMed ID Title Journal Year
27317874 RUNX2 promotes breast cancer bone metastasis by increasing integrin α5-mediated colonization

Lu, JT, Li, XQ, Feng, YM, Tan, CC, Wang, QS

Cancer Lett. 2016
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2016-09-20)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-20)
Cite Us!