Reactome | SRC phosphorylates RUNX3

SRC phosphorylates RUNX3

Stable Identifier

R-HSA-8937807

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated SRC phosphorylates RUNX3 in the cytosol, on multiple tyrosine residues. There are eleven tyrosine residues in RUNX3, but SRC target sites have not been determined. SRC-mediated phosphorylation of RUNX3 inhibits translocation of RUNX3 to the nucleus and is the underlying cause of cytosolic localization of RUNX3 in gastric and breast cancer (Goh et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20100835	Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm Goh, YM, Cinghu, S, Hong, ET, Lee, YS, Kim, JH, Jang, JW, Li, YH, Chi, XZ, Lee, KS, Wee, H, Ito, Y, Oh, BC, Bae, SC	J. Biol. Chem.	2010