SRC phosphorylates RUNX3

Stable Identifier
R-HSA-8937807
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated SRC phosphorylates RUNX3 in the cytosol, on multiple tyrosine residues. There are eleven tyrosine residues in RUNX3, but SRC target sites have not been determined. SRC-mediated phosphorylation of RUNX3 inhibits translocation of RUNX3 to the nucleus and is the underlying cause of cytosolic localization of RUNX3 in gastric and breast cancer (Goh et al. 2010).

Literature References
PubMed ID Title Journal Year
20100835 Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm

Goh, YM, Cinghu, S, Hong, ET, Lee, YS, Kim, JH, Jang, JW, Li, YH, Chi, XZ, Lee, KS, Wee, H, Ito, Y, Oh, BC, Bae, SC

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of MyrG-p-Y419-SRC:RUNX3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created