SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-8932955
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The transport of extracellular glucose (Glc) and galactose (Gal) into the cytosol, coupled to the uptake of two sodium ions for each hexose transported, is mediated by sodium/glucose cotransporter 1 (SLC5A1, also known as SGLT1), localized on the luminal surfaces of enterocytes (Wright et al. 2004). The specificity of SLC5A1 has been worked out by studying sugar transport in plasma membrane vesicles containing recombinant human SLC5A1 protein (Quick et al. 2003). Consistent with these in vitro results, children lacking functional SLC5A1 protein fail to absorb dietary glucose and galactose (Martin et al. 1996). The transport activity of SLC5A1 was decreased upon co-expression of regulatory solute carrier protein family 1 member 1 (RSC1A1, aka RS1). RSC1A1 exhibits glucose-dependent, short-term inhibition of SLC5A1 by inhibiting the release of vesicles from the trans-Golgi network (Veyhl et al. 2006).

Literature References
PubMed ID Title Journal Year
16788146 RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1

Veyhl, M, Keller, T, Gorboulev, V, Vernaleken, A, Koepsell, H

Am. J. Physiol. Renal Physiol. 2006
8563765 Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption

Martin, MG, Turk, E, Lostao, MP, Kerner, C, Wright, EM

Nat Genet 1996
12885248 Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles

Quick, M, Tomasevic, J, Wright, EM

Biochemistry 2003
15546855 Surprising versatility of Na+-glucose cotransporters: SLC5

Wright, EM, Loo, DD, Hirayama, BA, Turk, E

Physiology (Bethesda) 2004
Participants
Participates
Catalyst Activity

glucose:sodium symporter activity of SLC5A1 [plasma membrane]

This event is regulated
Negatively by
Orthologous Events
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