Upon activation by electrophiles or reactive oxygen species Nuclear factor erythroid 2-related (NFE2L2, NRF2) translocates to the nucleus.The mechanism by which this translocation occurs is not entirely elucidated. NFE2L2 possess two functional nuclear localization signals (NLS) one near the N-terminal region (murine NFE2L2 42-53 aa) and the other (residues 587-593) in the C-terminal region which may function in the nuclear import. It has also been demonstrated that importins might be involved in the nuclear translocation of NFE2L2. NFE2L2 associates especially with importin alpha 5 and beta 1 (Theodore et al. 2008).