RUNX1 binds ESR1

Stable Identifier
R-HSA-8931981
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX1 binds ESR1
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The RUNX1:CBFB complex binds the estrogen receptor alpha (ESR1). The interaction between RUNX1 and ESR1 is significantly enhanced upon ESR1 activation by estrogens (Stender et al. 2010).
Literature References
PubMed ID Title Journal Year
20547749 Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

Kraus, WL, Stender, JD, Benner, C, Charn, TH, Kim, K, Chang, KC, Katzenellenbogen, BS, Glass, CK, Komm, B

Mol. Cell. Biol. 2010
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Orthologous Events
RUNX1 binds ESR1 (Bos taurus)
RUNX1 binds ESR1 (Canis familiaris)
RUNX1 binds ESR1 (Drosophila melanogaster)
RUNX1 binds ESR1 (Gallus gallus)
RUNX1 binds ESR1 (Mus musculus)
RUNX1 binds ESR1 (Rattus norvegicus)
RUNX1 binds ESR1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-07-20)
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