N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A

Stable Identifier
R-HSA-8931974
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Eukaryotic elongation factor 1A (EEF1A) is an essential, highly methylated protein that facilitates translational elongation by delivering aminoacyl-tRNAs to ribosomes. EEF1AKMT1 (N6AMT2) trimethylates EEF1A at Lys-79, a high-stoichiometry N-terminal site that is conserved from yeast to humans (Hamey et al. 2016).

Literature References
PubMed ID Title Journal Year
26545399 Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human

Hamey, JJ, Winter, DL, Yagoub, D, Overall, CM, Hart-Smith, G, Wilkins, MR

Mol. Cell Proteomics 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-lysine N-methyltransferase activity of N6AMT2 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created