Release of GABA at the synapse

Stable Identifier
R-HSA-888589
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SVG |   | PPTX  | SBGN
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GABA synaptic vesicles are fused to the presynaptic terminal membrane with the help of SNARE complex proteins, synaptobrevin located in the synaptic vesicle, SNAP 25 and syntaxin located in the plasma membrane. Complexin optimizes partially assembled SNARES for Ca2+ dependent exocytosis. Fusion of the synaptic vesicle is triggered by the influx of Ca2+ through N, P/Q Ca2+ channels, which binds to synaptobrevin on the synaptic vesicles triggering a series of steps leading to fusion of the synaptic vesicle to the presynatic terminal membrane and release of GABA.

Literature References
PubMed ID Title Journal Year
12750892 The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids

Gasnier, B

Pflugers Arch 2004
19375301 Unconventional GABA release: mechanisms and function

Koch, U, Magnusson, AK

Curr Opin Neurobiol 2009
11017172 Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A

Deken, SL, Beckman, ML, Boos, L, Quick, MW

Nat Neurosci 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SNARE binding activity of Docked GABA loaded synaptic vesicle [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created