Release of GABA at the synapse

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GABA synaptic vesicles are fused to the presynaptic terminal membrane with the help of SNARE complex proteins, synaptobrevin located in the synaptic vesicle, SNAP 25 and syntaxin located in the plasma membrane. Complexin optimizes partially assembled SNARES for Ca2+ dependent exocytosis. Fusion of the synaptic vesicle is triggered by the influx of Ca2+ through N, P/Q Ca2+ channels, which binds to synaptobrevin on the synaptic vesicles triggering a series of steps leading to fusion of the synaptic vesicle to the presynatic terminal membrane and release of GABA.

Literature References
PubMed ID Title Journal Year
19375301 Unconventional GABA release: mechanisms and function

Magnusson, AK, Koch, U

Curr Opin Neurobiol 2009
12750892 The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids

Gasnier, B

Pflugers Arch 2004
11017172 Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A

Deken, SL, Quick, MW, Beckman, ML, Boos, L

Nat Neurosci 2000
Catalyst Activity

SNARE binding activity of Docked GABA loaded synaptic vesicle [cytosol]

Orthologous Events
Cite Us!