Reactome | Release of GABA at the synapse

Release of GABA at the synapse

Stable Identifier

R-HSA-888589

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, cytosol

ReviewStatus

5/5

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GABA synaptic vesicles are fused to the presynaptic terminal membrane with the help of SNARE complex proteins, synaptobrevin located in the synaptic vesicle, SNAP 25 and syntaxin located in the plasma membrane. Complexin optimizes partially assembled SNARES for Ca2+ dependent exocytosis. Fusion of the synaptic vesicle is triggered by the influx of Ca2+ through N, P/Q Ca2+ channels, which binds to synaptobrevin on the synaptic vesicles triggering a series of steps leading to fusion of the synaptic vesicle to the presynatic terminal membrane and release of GABA.

Literature References

PubMed ID	Title	Journal	Year
19375301	Unconventional GABA release: mechanisms and function Koch, U, Magnusson, AK	Curr Opin Neurobiol	2009
12750892	The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids Gasnier, B	Pflugers Arch	2004
11017172	Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A Deken, SL, Beckman, ML, Boos, L, Quick, MW	Nat Neurosci	2000