JAG1 gene expression is inhibited by RUNX3

Stable Identifier
R-HSA-8878212
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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JAG1 gene expression is inhibited by RUNX3
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Binding of RUNX3 to the JAG1 gene promoter inhibits transcription of JAG1, which correlates with reduced amount of cleaved JAG1 receptor, NOTCH1. There is an inverse correlation between the expression levels of RUNX3 and JAG1 in hepatocellular carcinoma (HCC) cell lines and tumor samples. HCC cell lines with higher RUNX3 levels have reduced tumorigenic capacity (Nishina et al. 2011).
Literature References
PubMed ID Title Journal Year
21637926 Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling

Nakanishi, Y, Matsubara, M, Iwamuro, M, Yagi, T, Tanaka, S, Yamamoto, K, Uemura, M, Kataoka, J, Takaoka, N, Shiraha, H, Horiguchi, S, Nishina, S

Oncol. Rep. 2011
Participants
Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
RUNX3:JAG1 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX3 [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-06-30)
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