RUNX3 binds SMAD3 and SMAD4

Stable Identifier
R-HSA-8878143
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX3 binds SMAD3 and SMAD4
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RUNX3 binds the complex of SMAD3 and SMAD4, formed in response to TGF-beta (TGFB1) signaling (Hanai et al. 1999, Chi et al. 2005).

Literature References
PubMed ID Title Journal Year
16135801 RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD

Sakakura, C, Lee, YH, Ito, K, Bae, SC, Ito, Y, Cha, EJ, Chi, XZ, Kaneda, A, Ushijima, T, Li, QL, Lee, KY, Kim, HR, Yang, JO, Kim, WJ

Mol. Cell. Biol. 2005
10531362 Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

Fukuchi, M, Imamura, T, Stavnezer, J, Chen, LF, Ishidou, Y, Ito, Y, Miyazono, K, Kawabata, M, Hanai, J, Shi, MJ, Guo, WH, Ohtani-Fujita, N, Kim, WY, Kanno, T

J. Biol. Chem. 1999
Participants
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Orthologous Events
RUNX3 binds SMAD3 and SMAD4 (Bos taurus)
RUNX3 binds SMAD3 and SMAD4 (Caenorhabditis elegans)
RUNX3 binds SMAD3 and SMAD4 (Canis familiaris)
RUNX3 binds SMAD3 and SMAD4 (Danio rerio)
RUNX3 binds SMAD3 and SMAD4 (Drosophila melanogaster)
RUNX3 binds SMAD3 and SMAD4 (Mus musculus)
RUNX3 binds SMAD3 and SMAD4 (Rattus norvegicus)
RUNX3 binds SMAD3 and SMAD4 (Sus scrofa)
RUNX3 binds SMAD3 and SMAD4 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-06-30)
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