Reactome | RUNX3 binds ZFHX3

RUNX3 binds ZFHX3

Stable Identifier

R-HSA-8878117

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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In response to TGF-beta (TGFB1) signaling, RUNX3 binds to the homeobox transcription factor and tumor suppressor ZFHX3 (ATBF1). The exact mechanism and regulation of RUNX3 and ATBF1 binding is not known (Mabuchi et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20599712	Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction Kubota, E, Mori, Y, Mizoshita, T, Tanaka, M, Kawaguchi, M, Mizushima, T, Miura, Y, Kim, TS, Kataoka, H, Ebi, M, Asai, K, Joh, T, Tanida, S, Shimura, T, Mabuchi, M, Kamiya, T	Biochem. Biophys. Res. Commun.	2010