Reactome | Activated AR binds RUNX2

Activated AR binds RUNX2

Stable Identifier

R-HSA-8877902

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - RUNX2 regulates bone development (Homo sapiens)
        
        RUNX2 regulates osteoblast differentiation (Homo sapiens)
        
        Activated AR binds RUNX2 (Homo sapiens)

General

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Androgen receptor (AR), activated by binding to androgens, forms a complex with RUNX2 (presumably associated with CBFB) in the nucleus. AR inhibits transcriptional activity of RUNX2, which may underlie AR-mediated attenuation of bone turnover. RUNX2 may play a tumor suppressor role in prostate cancer (Baniwal et al. 2009).

The complex of RUNX2 and AR is implicated in stimulation of the PSA gene transcription in response to TGF-beta signaling, but further experimental validation is needed (van der Deen et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19389811	Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA Baniwal, SK, Khalid, O, Sir, D, Buchanan, G, Coetzee, GA, Frenkel, B	Mol. Endocrinol.	2009