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AR:androgens [nucleoplasm]
Stable Identifier
R-HSA-5618087
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
HSP90 complexes [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:AR:Androgens [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
SHR:SH [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:AR:Androgens [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
RUNX2 regulates osteoblast differentiation (Homo sapiens)
Activated AR binds RUNX2 (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
RUNX2:AR:androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
RUNX2:MAF complex binds the BGLAP gene promoter (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
RUNX2:AR:androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
Demethylase KDM1A binds KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
Demethylase KDM4C binds KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
PKN1 stimulates association of AR with NCOA2 (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:NCOA2 [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
AR:androgens [nucleoplasm] (Homo sapiens)
Participants
components
Androgen [nucleoplasm]
AR [nucleoplasm]
(Homo sapiens)
Participates
as a member of
SHR:SH [nucleoplasm] (Homo sapiens)
as a component of
HSP90:ATP:PTGES3:FKBP52:AR:Androgens [nucleoplasm] (Homo sapiens)
RUNX2:AR:androgen [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:NCOA2 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm] (Homo sapiens)
as an input of
Activated AR binds RUNX2 (Homo sapiens)
Inferred To
AR:androgens [nucleoplasm]
(Bos taurus)
AR:androgens [nucleoplasm]
(Canis familiaris)
AR:androgens [nucleoplasm]
(Danio rerio)
AR:androgens [nucleoplasm]
(Dictyostelium discoideum)
AR:androgens [nucleoplasm]
(Drosophila melanogaster)
AR:androgens [nucleoplasm]
(Gallus gallus)
AR:androgens [nucleoplasm]
(Mus musculus)
AR:androgens [nucleoplasm]
(Plasmodium falciparum)
AR:androgens [nucleoplasm]
(Rattus norvegicus)
AR:androgens [nucleoplasm]
(Saccharomyces cerevisiae)
AR:androgens [nucleoplasm]
(Schizosaccharomyces pombe)
AR:androgens [nucleoplasm]
(Sus scrofa)
AR:androgens [nucleoplasm]
(Xenopus tropicalis)
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