Reactome | p-Y-CBL:GRB2 [cytosol]

p-Y-CBL:GRB2

Stable Identifier

R-HSA-8876351

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - Negative regulation of MET activity (Homo sapiens)
      - CBL monoubiquitinates activated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
      - EPS15 and HGS bind ubiquitinated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
      - MET phosphorylates CBL (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        p-Y-CBL:GRB2 [cytosol] (Homo sapiens)

Participants

components

Participant Of

hasComponent

Inferred To

p-Y-CBL:GRB2 [cytosol] (Bos taurus)

p-Y-CBL:GRB2 [cytosol] (Caenorhabditis elegans)

p-Y-CBL:GRB2 [cytosol] (Canis familiaris)

p-Y-CBL:GRB2 [cytosol] (Danio rerio)

p-Y-CBL:GRB2 [cytosol] (Gallus gallus)

p-Y-CBL:GRB2 [cytosol] (Mus musculus)

p-Y-CBL:GRB2 [cytosol] (Rattus norvegicus)

p-Y-CBL:GRB2 [cytosol] (Sus scrofa)

p-Y-CBL:GRB2 [cytosol] (Taeniopygia guttata)

p-Y-CBL:GRB2 [cytosol] (Xenopus tropicalis)