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p-Y-CBL
Stable Identifier
R-HSA-8875457
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Listeria monocytogenes entry into host cells (Homo sapiens)
InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)
CBL monoubiquitinates InlB-bound MET (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane, cell wall] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
InlB:p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane, cell wall] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
CBL recruits CIN85:endophilin complex to InlB-bound MET (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane, cell wall] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL:CIN85:endophilin [plasma membrane, cell wall] (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane, cell wall] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL:CIN85:endophilin [plasma membrane, cell wall] (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane, cell wall] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET:GRB2-1:p-Y-CBL:CIN85:endophilin:EPS15:HGS:STAM [plasma membrane, cell wall] (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL:CIN85:endophilin [plasma membrane, cell wall] (Homo sapiens)
InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane, cell wall] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
InlB-activated MET phosphorylates CBL (Homo sapiens)
InlB:p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane, cell wall] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
CBL monoubiquitinates activated MET (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
EPS15 and HGS bind ubiquitinated MET (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
MET phosphorylates CBL (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL:GRB2 [cytosol] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
p-Y-CBL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22681 CBL
Gene Names
CBL, CBL2, RNF55
Chain
chain:1-906
Reference Genes
BioGPS Gene:867 CBL
COSMIC (genes):CBL CBL
CTD Gene:867 CBL
dbSNP Gene:867 CBL
ENSEMBL:ENSG00000110395 CBL
HGNC:1541 CBL
KEGG Gene (Homo sapiens):hsa:867 CBL
Monarch:867 CBL
NCBI Gene:867 CBL
OMIM:165360 CBL
UCSC:P22681 CBL
Reference Transcript
RefSeq:NM_005188.3 CBL
Other Identifiers
0001230102
11724807_at
11724808_at
11724809_at
11724810_at
16732296
1B47
1FBV
1YVH
206607_at
225231_at
225234_at
229010_at
243475_at
27956
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3352072
3352073
3352074
3352075
3352079
3352087
3352088
3352089
3352091
3352092
3352093
3352094
3352095
3352097
3352098
3352102
3352104
3352105
3352106
3352108
3352109
3352110
3352111
3352112
3352113
3352114
3352115
3352116
3352117
3352118
34416_at
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4350
47569_at
4A49
4A4B
4A4C
4GPL
51017_at
55605_at
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
68600_at
7944493
867
A_14_P135711
A_14_P200324
A_23_P339191
A_23_P53226
A_33_P3256033
CAB004350
CBL
CBL-201
CCDS8418
ENSG00000110395
ENSP00000264033
ENST00000264033
EntrezGene:867
g4885116_3p_at
GE59823
GE87401
GE88439
GO:0000209
GO:0001784
GO:0003700
GO:0004842
GO:0004871
GO:0005154
GO:0005509
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005925
GO:0006355
GO:0006513
GO:0006974
GO:0007166
GO:0007173
GO:0007175
GO:0007179
GO:0008543
GO:0008584
GO:0010332
GO:0014068
GO:0014823
GO:0016020
GO:0016567
GO:0016600
GO:0016740
GO:0017124
GO:0019901
GO:0023051
GO:0030424
GO:0030426
GO:0030971
GO:0033574
GO:0035635
GO:0036120
GO:0036312
GO:0042059
GO:0042594
GO:0042629
GO:0042787
GO:0043066
GO:0043303
GO:0045121
GO:0045296
GO:0045471
GO:0045742
GO:0046677
GO:0046872
GO:0046875
GO:0048260
GO:0048471
GO:0061024
GO:0061630
GO:0070997
GO:0071364
GO:0090650
GO:1901215
GO:1990090
GO:1990782
HGNC:1541
HPA027956
Hs.196521.0.A1_3p_at
Hs.41324.0.A1_3p_at
Hs.504096
Hs.90960.0.A1_3p_at
Hs.90960.0.A2_3p_at
ILMN_1716080
ILMN_2181968
LRG_608
LRG_608t1
MIM:165360
MIM:607785
MIM:613563
NM_005188
NP_005179
PF00627
PF02262
PF02761
PF02762
PF14447
PH_hs_0022112
PH_hs_0031180
SM00165
SM00184
TC11001089.hg
TC11002905.hg
uc001pwe.6
UPI000013D4A7
X57110_s_at
XM_017018511
XP_016874000
Participant Of
hasComponent
HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane]
HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane]
p-Y-CBL:GRB2 [cytosol]
Other forms of this molecule
p-Y371-CBL [plasma membrane]
p-Y371-CBL [cytosol]
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
p-Y700,Y731,Y774-CBL [cytosol]
CBL [cytosol]
CBL [plasma membrane]
Inferred To
Homologues of p-Y-CBL [cytosol] (Caenorhabditis elegans)
Homologues of p-Y-CBL [cytosol] (Taeniopygia guttata)
phospho-p-Y-CBL [cytosol] (Bos taurus)
phospho-p-Y-CBL [cytosol] (Caenorhabditis elegans)
phospho-p-Y-CBL [cytosol] (Canis familiaris)
phospho-p-Y-CBL [cytosol] (Danio rerio)
phospho-p-Y-CBL [cytosol] (Gallus gallus)
phospho-p-Y-CBL [cytosol] (Mus musculus)
phospho-p-Y-CBL [cytosol] (Rattus norvegicus)
phospho-p-Y-CBL [cytosol] (Sus scrofa)
phospho-p-Y-CBL [cytosol] (Taeniopygia guttata)
phospho-p-Y-CBL [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_005179.2
Brenda
2.3.2.27
GeneCards
P22681
DOCK Blaster
5HKW
,
5HL0
,
4GPL
,
2CBL
,
5HKY
,
5HKX
,
1B47
,
3OB1
,
1YVH
,
2Y1N
,
3BUO
,
2Y1M
,
3BUN
,
3BUX
,
3BUW
,
5HKZ
,
4A49
,
2OO9
,
4A4C
,
4A4B
,
5J3X
,
3BUM
,
3PLF
,
1FBV
,
3OB2
PRO
P22681
Orphanet
19464
HMDB Protein
HMDBP07558
PDB
5HL0
,
2K4D
,
2OO9
,
5J3X
,
2Y1M
,
5O76
,
2Y1N
,
3BUM
,
1B47
,
4GPL
,
1FBV
,
5HKW
,
1YVH
,
3OB1
,
3BUX
,
3BUW
,
3BUO
,
3BUN
,
4A4C
,
4A4B
,
4A49
,
3PLF
,
3OB2
,
5HKZ
,
2JUJ
,
5HKY
,
2CBL
,
5HKX
Interactors (47)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [cytosol]
(R-HSA-182957)
SH3KBP1 [plasma membrane]
(R-HSA-182955)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.97
25
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.964
26
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.955
15
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.94
16
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.878
10
UniProt:P08581 MET
7
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.864
17
UniProt:O43597 SPRY2
8
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
SPRY2 [plasma membrane]
(R-HSA-182924)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
0.856
17
UniProt:P12931 SRC
4
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.845
8
UniProt:P46109 CRKL
2
CRKL [endosome]
(R-HSA-2980683)
CRKL [cytosol]
(R-HSA-354384)
0.826
8
UniProt:P06241 FYN
5
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.798
6
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.796
7
UniProt:P62994 Grb2
3
GRB2-1 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-55929)
GRB2-1 [cytosol]
(R-RNO-74686)
0.78
5
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
0.77
5
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.758
6
UniProt:P06239 LCK
4
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.75
4
UniProt:P43405 SYK
6
SYK [plasma membrane]
(R-HSA-139844)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
p-Y348-SYK [cytosol]
(R-HSA-437953)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
SYK [cytosol]
(R-HSA-58268)
p-6Y-SYK [cytosol]
(R-HSA-983586)
0.743
7
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.729
12
UniProt:P07949 RET
2
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
RET [plasma membrane]
(R-HSA-8853797)
0.697
8
UniProt:O14492 SH2B2
2
SH2B2 [cytosol]
(R-HSA-112195)
p-Y629-SH2B2 [cytosol]
(R-HSA-112184)
0.656
7
UniProt:P31946 YWHAB
2
YWHAB [endosome]
(R-HSA-190058)
YWHAB [cytosol]
(R-HSA-48888)
0.643
3
UniProt:O00459 PIK3R2
2
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
0.621
4
UniProt:Q9C004 SPY4
0.611
9
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.611
3
UniProt:P62837 UBE2D2
4
Ub-C85-UBE2D2 [cytosol]
(R-HSA-8864214)
Ub-C85-UBE2D2 [nucleoplasm]
(R-HSA-8864153)
UBE2D2 [nucleoplasm]
(R-HSA-8852067)
UBE2D2 [cytosol]
(R-HSA-934628)
0.611
4
UniProt:P43403 ZAP70
3
p-Y493-ZAP70 [cytosol]
(R-HSA-202368)
ZAP70 [cytosol]
(R-HSA-202397)
p-Y315,Y493-ZAP70 [cytosol]
(R-HSA-202252)
0.611
3
UniProt:P39688 Fyn
8
phospho-MyrG-p-Y420-FYN [plasma membrane]
(R-MMU-1810410)
Fyn [cytosol]
(R-MMU-420333)
phospho-p-Y420-FYN [cytosol]
(R-MMU-391821)
phospho-MyrG,p-Y420-FYN-1 [plasma membrane]
(R-MMU-9032530)
MyrG,p-Y420-Fyn [plasma membrane]
(R-MMU-9037733)
pFyn (420) [cytosol]
(R-MMU-420335)
pFyn(Y531) [cytosol]
(R-MMU-420350)
phospho-p-S21,Y420-FYN [cytosol]
(R-MMU-5218745)
0.591
3
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.591
9
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.57
4
UniProt:P08487 PLCG1
0.556
3
UniProt:P55085 F2RL1
1
F2RL1(37-397) [plasma membrane]
(R-HSA-389418)
0.556
3
UniProt:Q13196 Q13196
0.544
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.527
2
UniProt:P06240 Lck
5
phospho-p-Y394-LCK [plasma membrane]
(R-MMU-8857940)
Lck [cytosol]
(R-MMU-539041)
phospho-p-Y505-LCK [plasma membrane]
(R-MMU-202159)
phospho-p-Y394-LCK [cytosol]
(R-MMU-202308)
LCK [cytosol]
(R-MMU-167609)
0.524
2
UniProt:P08631-2 HCK
0.524
2
UniProt:Q8IZP0-2 ABI1
0.524
3
UniProt:F1SDV6
5
phospho-p-Y771,Y783-PLCG1 [plasma membrane]
(R-SSC-1169084)
PLCG1 [plasma membrane]
(R-SSC-167682)
PLCG1 [cytosol]
(R-SSC-202320)
phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-SSC-202357)
phospho-p-4Y-PLCG1 [plasma membrane]
(R-SSC-167679)
0.524
2
UniProt:Q99962 SH3GL2
4
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [plasma membrane]
(R-HSA-177495)
0.499
2
UniProt:Q12929 EPS8
0.488
2
UniProt:P42229 STAT5A
5
p-STAT5A [cytosol]
(R-HSA-8980151)
p-STAT5A [nucleoplasm]
(R-HSA-8982836)
p-Y694-STAT5A [nucleoplasm]
(R-HSA-507995)
p-Y694-STAT5A [cytosol]
(R-HSA-507936)
STAT5A [cytosol]
(R-HSA-380747)
0.488
2
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
0.488
2
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.488
2
UniProt:P46108-2 CRK
0.488
2
UniProt:P27986-2 PIK3R1
0.488
2
UniProt:P26450 Pik3r1
4
Pi3k-p85 alpha [cytosol]
(R-MMU-1295777)
K63polyUb-PIK3R1 [cytosol]
(R-MMU-3080572)
PIK3R1 [cytosol]
(R-MMU-74789)
PIK3R1 [plasma membrane]
(R-MMU-198365)
0.462
2
UniProt:A9UF07 A9UF07
0.462
4
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