CBL monoubiquitinates InlB-bound MET

Stable Identifier
R-HSA-8876258
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane, peptidoglycan-based cell wall, cytosol
ReviewStatus
5/5
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CBL monoubiquitinates InlB-bound MET
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CBL promotes monoubiquitination of MET receptor that is activated by binding of the Listeria monocytogenes cell wall protein InlB. CBL-mediated monoubiquitination of MET promotes endocytosis and entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).
Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells

Veiga, E, Cossart, P

Nat. Cell Biol. 2005
Participants
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Output
Entity On Other Cell
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as an event of
Catalyst Activity

ubiquitin protein ligase activity of InlB:p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane]

Physical Entity
InlB:p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Disease
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Schwerk, C  (2016-10-25)
Created
Orlic-Milacic, M  (2016-06-10)
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