CBL monoubiquitinates InlB-bound MET

Stable Identifier
R-HSA-8876258
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
Locations in the PathwayBrowser
General
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CBL promotes monoubiquitination of MET receptor that is activated by binding of the Listeria monocytogenes cell wall protein InlB. CBL-mediated monoubiquitination of MET promotes endocytosis and entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).

Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells

Veiga, E, Cossart, P

Nat. Cell Biol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of InlB:p-4Y-MET dimer:GRB2-1:p-Y-CBL [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Reviewed
Created
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