MET phosphorylates CBL

Stable Identifier
R-HSA-8875451
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MET phosphorylates CBL on unknown tyrosine residues. This is thought to precede CBL-mediated MET ubiquitination and may promote stronger interaction of CBL with the activated MET receptor complex (Peschard et al. 2001, Petrelli et al. 2002).

Literature References
PubMed ID Title Journal Year
11894096 The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

Gilestro, GF, Migone, N, Lanzardo, S, Giordano, S, Comoglio, PM, Petrelli, A

Nature 2002
11741535 Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

Band, H, Peschard, P, Naujokas, MA, Fournier, TM, Park, M, Lamorte, L, Langdon, WY

Mol. Cell 2001
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane]

Orthologous Events
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Reviewed
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