MET phosphorylates CBL

Stable Identifier
R-HSA-8875451
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MET phosphorylates CBL on unknown tyrosine residues. This is thought to precede CBL-mediated MET ubiquitination and may promote stronger interaction of CBL with the activated MET receptor complex (Peschard et al. 2001, Petrelli et al. 2002).

Literature References
PubMed ID Title Journal Year
11741535 Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

Peschard, P, Fournier, TM, Lamorte, L, Naujokas, MA, Band, H, Langdon, WY, Park, M

Mol. Cell 2001
11894096 The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

Petrelli, A, Gilestro, GF, Lanzardo, S, Comoglio, PM, Migone, N, Giordano, S

Nature 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created