Reactome | MET phosphorylates CBL

MET phosphorylates CBL

Stable Identifier

R-HSA-8875451

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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MET phosphorylates CBL on unknown tyrosine residues. This is thought to precede CBL-mediated MET ubiquitination and may promote stronger interaction of CBL with the activated MET receptor complex (Peschard et al. 2001, Petrelli et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11894096	The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met Petrelli, A, Gilestro, GF, Lanzardo, S, Comoglio, PM, Migone, N, Giordano, S	Nature	2002
11741535	Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein Peschard, P, Fournier, TM, Lamorte, L, Naujokas, MA, Band, H, Langdon, WY, Park, M	Mol. Cell	2001