InlB-activated MET phosphorylates CBL

Stable Identifier
R-HSA-8876246
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane, peptidoglycan-based cell wall, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
InlB-activated MET phosphorylates CBL
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of InlB to MET receptor induces CBL phosphorylation on tyrosine residue(s). Based on the analogy with HGF-induced MET signaling, MET receptor activated by binding of the Listeria monocytogenes protein InlB phosphorylates CBL, promoting stronger interaction of CBL with MET (Peschard et al. 2001, Petrelli et al. 2002).
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of InlB:p-4Y-MET dimer:GRB2-1:CBL [plasma membrane]

Physical Entity
InlB:p-4Y-MET dimer:GRB2-1:CBL [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
MET phosphorylates CBL (Homo sapiens)
Disease
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Schwerk, C  (2016-10-25)
Created
Orlic-Milacic, M  (2016-06-10)
Cite Us!