USP8 deubiquitinates LRIG1

Stable Identifier
R-HSA-8875443
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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USP8 deubiquitinates LRIG1
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The ubiquitin hydrolase USP8 can deubiquitinate LRIG1, thus interfering with LRIG1-mediated MET downregulation (Oh et al. 2014).

Literature References
PubMed ID Title Journal Year
24828152 USP8 modulates ubiquitination of LRIG1 for Met degradation

Oh, YM, Lee, SB, Choi, J, Suh, HY, Shim, S, Song, YJ, Kim, B, Lee, JM, Oh, SJ, Jeong, Y, Cheong, KH, Song, PH, Kim, KA

Sci Rep 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP8 [cytosol]
Physical Entity
USP8 [cytosol]
Activity
thiol-dependent ubiquitin-specific protease activity (0004843)
Orthologous Events
USP8 deubiquitinates LRIG1 (Gallus gallus)
USP8 deubiquitinates LRIG1 (Mus musculus)
USP8 deubiquitinates LRIG1 (Rattus norvegicus)
USP8 deubiquitinates LRIG1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-06-05)
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