USP8 deubiquitinates LRIG1

Stable Identifier
R-HSA-8875443
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
USP8 deubiquitinates LRIG1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The ubiquitin hydrolase USP8 can deubiquitinate LRIG1, thus interfering with LRIG1-mediated MET downregulation (Oh et al. 2014).
Literature References
PubMed ID Title Journal Year
24828152 USP8 modulates ubiquitination of LRIG1 for Met degradation

Oh, YM, Lee, SB, Choi, J, Suh, HY, Shim, S, Song, YJ, Kim, B, Lee, JM, Oh, SJ, Jeong, Y, Cheong, KH, Song, PH, Kim, KA

Sci Rep 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of USP8 [cytosol]

Physical Entity
USP8 [cytosol] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP8 deubiquitinates LRIG1 (Bos taurus)
USP8 deubiquitinates LRIG1 (Canis familiaris)
USP8 deubiquitinates LRIG1 (Gallus gallus)
USP8 deubiquitinates LRIG1 (Mus musculus)
USP8 deubiquitinates LRIG1 (Rattus norvegicus)
USP8 deubiquitinates LRIG1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-06-05)
Cite Us!