USP8 deubiquitinates LRIG1

Stable Identifier
R-HSA-8875443
Type
Reaction
Species
Homo sapiens
Compartment
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The ubiquitin hydrolase USP8 can deubiquitinate LRIG1, thus interfering with LRIG1-mediated MET downregulation (Oh et al. 2014).

Literature References
PubMed ID Title Journal Year
24828152 USP8 modulates ubiquitination of LRIG1 for Met degradation

Shim, S, Kim, KA, Lee, JM, Oh, SJ, Choi, J, Cheong, KH, Suh, HY, Oh, YM, Song, PH, Song, YJ, Lee, SB, Kim, B, Jeong, Y

Sci Rep 2014
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP8 [cytosol]

Orthologous Events
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