SLC27A3 ligates CoA-SH to VLCFA

Stable Identifier
R-HSA-8875077
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
ReviewStatus
5/5
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SLC27A3 ligates CoA-SH to VLCFA
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Acyl-coenzyme A synthetases catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid oxidation. Members of the long chain acyl-coenzyme A synthetases (ACSVL) subfamily were originally thought to be fatty acid transport proteins (FATPs), hence their approved gene names and symbols are “solute carrier family 27 (fatty acid transporter) member x" (SLC27Ax) but their transport function has never been proven. Instead, their amino acid sequence contains two highly conserved motifs characteristic of acyl-CoA synthetases. Long-chain fatty acid transport protein 3 (SLC27A3, aka ACSVL3, FATP3) preferentially ligates CoA-SH to very long-chain fatty acids (VLCFA) (Watkins et al. 2007). The activity of human SLC27A3 is inferred from mouse Slc27a3 functional studies (Pei et al. 2004).
Literature References
PubMed ID Title Journal Year
15469937 Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells

Berger, J, Watkins, PA, Jia, Z, Pei, Z, Fraisl, P, Forss-Petter, S

J. Biol. Chem. 2004
17762044 Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Pevsner, J, Jia, Z, Watkins, PA, Maiguel, D

J. Lipid Res. 2007
Participants
Input
Output
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as an event of
Catalyst Activity

very long-chain fatty acid-CoA ligase activity of SLC27A3 [mitochondrial matrix]

Physical Entity
SLC27A3 [mitochondrial matrix] (Homo sapiens)
Activity
very long-chain fatty acid-CoA ligase activity (GO:0031957)
Inferred From
Slc27a3 ligates CoA to VLCFA (Mus musculus)
Cross References
RHEA
Rhea
Authored
Jassal, B  (2016-06-01)
Reviewed
D'Eustachio, P  (2016-07-15)
Created
Jassal, B  (2016-06-01)
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