MBTPS2 (S2P) cleaves CREB3L1

Stable Identifier
R-HSA-8874194
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
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MBTPS2 (S2P) cleaves CREB3L1
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After cleavage by MBTPS1 (S1P), CREB3L1 (OASIS) is cleaved by MBTPS2, yielding a 60 kDal cytosolic product (S2P) (Denard et al. 2011, Denard et al. 2012, Mellor et al. 2013, Rose et al. 2014, Ward et al. 2016, inferred from mouse homologs). By inference from SREBFs (SREBPs) the cleavage is believed to occur near the cytoplasmic face of the transmembrane domain about amino acid residue 375. The cleavage releases the N-terminal cytoplasmic domain into the cytosol.

Literature References
PubMed ID Title Journal Year
21767813 The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells

Chen, Q, Gay, A, Chen, Y, Denard, B, Huang, H, Seemann, J, Ye, J

Cell Host Microbe 2011
24126059 CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis

Carlsen, SA, Calvert, B, Anderson, DH, Deibert, L, Bonham, K, Mellor, P

Mol. Cell. Biol. 2013
23256041 Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

Denard, B, Lee, C, Ye, J

Elife 2012
26810754 Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

Sarker, S, Anderson, DH, Smith, SE, Kendall, S, Just, NA, Carlsen, SA, Saxena, A, Alvi, R, Ward, AK, Phillips, Z, Vizeacoumar, FS, Mellor, P, Vizeacoumar, FJ

Breast Cancer Res. 2016
25625847 OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro

Dahl, E, Heer, M, Dierichs, L, Schubert, C, Rose, M, Heidenreich, A, Knuchel, R, Gaisa, NT

Epigenetics 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of MBTPS2 [Golgi membrane]

Physical Entity
MBTPS2 [Golgi membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Mbtps2 (S2P) cleaves Creb3l1 (Oasis) (Mus musculus)
Authored
May, B  (2016-05-21)
Reviewed
Schröder, M  (2017-02-25)
Created
May, B  (2016-05-21)
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