Mbtps2 (S2P) cleaves Creb3l1 (Oasis)

Stable Identifier
R-MMU-8874364
Type
Reaction [transition]
Species
Mus musculus
Compartment
Golgi membrane, cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mbtps2 (S2P) cleaves Creb3l1 (Oasis)

After cleavage by Mbtps1 (S1P), Creb3l1 (Oasis) is cleaved (Kondo et al. 2012) by Mbtps22 (S2P) (Kondo et al. 2005, Murakami et al. 2006). By inference from SREBFs (SREBPs) the cleavage is believed to occur near the cytoplasmic face of the transmembrane domain about amino acid residue 374.

Literature References
PubMed ID Title Journal Year
16417584 Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress

Murakami, T, Kondo, S, Ogata, M, Kanemoto, S, Saito, A, Wanaka, A, Imaizumi, K

J. Neurochem. 2006
22705851 Activation of OASIS family, ER stress transducers, is dependent on its stabilization

Kondo, S, Hino, SI, Saito, A, Kanemoto, S, Kawasaki, N, Asada, R, Izumi, S, Iwamoto, H, Oki, M, Miyagi, H, Kaneko, M, Nomura, Y, Urano, F, Imaizumi, K

Cell Death Differ. 2012
15665855 OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

Kondo, S, Murakami, T, Tatsumi, K, Ogata, M, Kanemoto, S, Otori, K, Iseki, K, Wanaka, A, Imaizumi, K

Nat. Cell Biol. 2005
Participants
Input
Output
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of Mbtps2 [Golgi membrane]
Physical Entity
Mbtps2 [Golgi membrane]
Activity
metalloendopeptidase activity (0004222)
Orthologous Events
MBTPS2 (S2P) cleaves CREB3L1 (Homo sapiens)
Authored
May, B  (2016-05-22)
Reviewed
Schröder, M  (2017-02-25)
Created
May, B  (2016-05-23)
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