p-Y397-PTK2 binds SRC

Stable Identifier
R-HSA-8874083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated tyrosine Y397 in the FERM domain of PTK2 (FAK1), along with an adjacent proline-rich motif, creates a docking site for the SRC kinase (Schaller et al. 1994, Xing et al. 1994, Thomas et al. 1998). It has not been specifically tested in this context whether PTK2 promotes SRC activation, and SRC is therefore represented in its active form.

Literature References
PubMed ID Title Journal Year
9417118 SH2- and SH3-mediated interactions between focal adhesion kinase and Src

Thomas, JW, Ellis, B, Boerner, RJ, Knight, WB, White, GC, Schaller, MD

J. Biol. Chem. 1998
8054685 Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

Xing, Z, Chen, HC, Nowlen, JK, Taylor, SJ, Shalloway, D, Guan, JL

Mol Biol Cell 1994
7509446 Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

Schaller, MD, Hildebrand, JD, Shannon, JD, Fox, JW, Vines, RR, Parsons, JT

Mol Cell Biol 1994
Participants
Participant Of
Orthologous Events
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