p-Y397-PTK2 binds SRC

Stable Identifier
Reaction [binding]
Homo sapiens
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Phosphorylated tyrosine Y397 in the FERM domain of PTK2 (FAK1), along with an adjacent proline-rich motif, creates a docking site for the SRC kinase (Schaller et al. 1994, Xing et al. 1994, Thomas et al. 1998). It has not been specifically tested in this context whether PTK2 promotes SRC activation, and SRC is therefore represented in its active form.

Literature References
PubMed ID Title Journal Year
8054685 Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

Guan, JL, Nowlen, JK, Taylor, SJ, Chen, HC, Shalloway, D, Xing, Z

Mol Biol Cell 1994
9417118 SH2- and SH3-mediated interactions between focal adhesion kinase and Src

Ellis, B, Knight, WB, White, GC, Thomas, JW, Boerner, RJ, Schaller, MD

J. Biol. Chem. 1998
7509446 Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

Hildebrand, JD, Shannon, JD, Fox, JW, Schaller, MD, Parsons, JT, Vines, RR

Mol Cell Biol 1994
Orthologous Events
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