Reactome | p-Y397-PTK2 binds SRC

p-Y397-PTK2 binds SRC

Stable Identifier

R-HSA-8874083

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated tyrosine Y397 in the FERM domain of PTK2 (FAK1), along with an adjacent proline-rich motif, creates a docking site for the SRC kinase (Schaller et al. 1994, Xing et al. 1994, Thomas et al. 1998). It has not been specifically tested in this context whether PTK2 promotes SRC activation, and SRC is therefore represented in its active form.

Literature References

PubMed ID	Title	Journal	Year
8054685	Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain Guan, JL, Nowlen, JK, Taylor, SJ, Chen, HC, Shalloway, D, Xing, Z	Mol Biol Cell	1994
9417118	SH2- and SH3-mediated interactions between focal adhesion kinase and Src Ellis, B, Knight, WB, White, GC, Thomas, JW, Boerner, RJ, Schaller, MD	J. Biol. Chem.	1998
7509446	Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src Hildebrand, JD, Shannon, JD, Fox, JW, Schaller, MD, Parsons, JT, Vines, RR	Mol Cell Biol	1994