Reactome | GGC-RAB1A [cytosol]

GGC-RAB1A [cytosol]

Stable Identifier

R-HSA-8870424

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RAB1, Ras-related protein Rab-1A

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Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
      - TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)
        
        GGC-RAB1:GDP:GDIs,CHMs [cytosol] (Homo sapiens)
        
        GGC-RAB1:GDP [cytosol] (Homo sapiens)
        
        GGC-RAB1A:GDP [cytosol] (Homo sapiens)
        
        GGC-RAB1A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62820 RAB1A

Gene Names

RAB1A, RAB1

Chain

initiator methionine:, chain:2-205

Reference Genes

BioGPS Gene:5861 RAB1A

COSMIC (genes):RAB1A RAB1A

CTD Gene:5861 RAB1A

dbSNP Gene:5861 RAB1A

ENSEMBL:ENSG00000138069 RAB1A

ENSEMBL_homo_sapiens_GENE:ENSG00000138069.18 RAB1A

HGNC:9758 RAB1A

KEGG Gene (Homo sapiens):5861 RAB1A

Monarch:5861 RAB1A

NCBI Gene:5861 RAB1A

OMIM:179508 RAB1A

UCSC:P62820 RAB1A

Reference Transcript

Other Identifiers

1074_at

11717723_s_at

11717724_a_at

11717725_x_at

11739327_x_at

16898394

207791_PM_s_at

207791_s_at

208724_PM_s_at

208724_s_at

213440_PM_at

213440_at

239570_PM_at

239570_at

2556668

2556672

2556673

2556674

2556675

2556676

2556677

2556678

2556679

2556682

2556685

2556694

2556699

2556710

2556711

2556712

2556713

2592311

32605_r_at

34392_s_at

34393_r_at

5861

79683_at

8052680

A_23_P250283

A_23_P382148

A_24_P251351

A_33_P3371055

GE78984

GE890640

GO:0000045

GO:0000139

GO:0000166

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005737

GO:0005768

GO:0005769

GO:0005783

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006897

GO:0006914

GO:0007018

GO:0007030

GO:0007155

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016477

GO:0016787

GO:0019068

GO:0023052

GO:0030252

GO:0030658

GO:0031410

GO:0032402

GO:0032757

GO:0034446

GO:0042470

GO:0042742

GO:0043226

GO:0045296

GO:0047496

GO:0048870

GO:0061024

GO:0070062

GO:0090110

GO:0098542

GO:0098772

GO:1901135

GO:1903020

HMNXSV003023316

Hs.144137.0.A1_3p_at

Hs.79507.2.A1_3p_at

Hs.79507.2.A1_3p_x_at

ILMN_2118864

M28209_at

PH_hs_0012652

TC02001922.hg

g12654174_3p_a_at

g4758987_3p_a_at

Participates

as a component of

GGC-RAB1A:GDP [cytosol] (Homo sapiens)

as a member of

GGC-RABs [cytosol] (Homo sapiens)

Other forms of this molecule

RAB1A [endoplasmic reticulum membrane]

GGC-RAB1A [transport vesicle membrane]

RAB1A [transport vesicle]

RAB1A [endoplasmic reticulum-Golgi intermediate compartment membrane]

p-T195-RAB1A [Golgi membrane]

RAB1A [Golgi membrane]

RAB1A [cytosol]

Inferred To

RAB1A [cytosol] (Bos taurus)

rab-1 [cytosol] (Caenorhabditis elegans)

Rab1 [cytosol] (Drosophila melanogaster)

GGC-RAB1A [cytosol] (Canis familiaris)

GGC-RAB1A [cytosol] (Danio rerio)

GGC-RAB1A [cytosol] (Dictyostelium discoideum)

GGC-RAB1A [cytosol] (Mus musculus)

GGC-RAB1A [cytosol] (Plasmodium falciparum)

GGC-RAB1A [cytosol] (Rattus norvegicus)

GGC-RAB1A [cytosol] (Saccharomyces cerevisiae)

GGC-RAB1A [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 204

Coordinate

204

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 205

Coordinate

205

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_004152.1, NP_056358.1

OpenTargets

ENSG00000138069

GeneCards

P62820

HPA

ENSG00000138069-RAB1A

Ensembl

ENST00000649427, ENST00000398529, ENSP00000387286, ENSP00000381540, ENSP00000497078, ENSG00000138069, ENSP00000386451, ENST00000409892, ENST00000409784

PRO

P62820

Pharos - Targets

P62820

HMDB Protein

HMDBP01940

PDB

3TKL, 2WWX, 4FMD, 7EQ2, 4FME, 4FMB, 3L0I, 3SFV, 4FMC, 2FOL, 4IRU, 4JVS

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.609	6
UniProt:Q92696 RABGGTA	2	RABGGTA [plasma membrane] (R-HSA-6801086) RABGGTA [cytosol] (R-HSA-8870418)	0.527	2
UniProt:P24386 CHM	1	CHM [cytosol] (R-HSA-6801097)	0.527	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.527	3