Reactome | PLEKHA2 [plasma membrane]

PLEKHA2 [plasma membrane]

Stable Identifier

R-HSA-8870329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Pleckstrin homology domain-containing family A member 2, PKHA2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - PI Metabolism (Homo sapiens)
      - Synthesis of PIPs at the plasma membrane (Homo sapiens)
        
        PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Homo sapiens)
        
        PTPN13:PLEKHA1,2 [plasma membrane] (Homo sapiens)
        
        PTPN13:PLEKHA2 [plasma membrane] (Homo sapiens)
        
        PLEKHA2 [plasma membrane] (Homo sapiens)
        
        PTPN13:PLEKHA1,2:PIP2 [plasma membrane] (Homo sapiens)
        
        PTPN13:PLEKHA1,2 [plasma membrane] (Homo sapiens)
        
        PTPN13:PLEKHA2 [plasma membrane] (Homo sapiens)
        
        PLEKHA2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HB19 PLEKHA2

Gene Names

PLEKHA2, TAPP2

Chain

chain:1-425

Reference Genes

BioGPS Gene:59339 PLEKHA2

COSMIC (genes):PLEKHA2 PLEKHA2

CTD Gene:59339 PLEKHA2

dbSNP Gene:59339 PLEKHA2

ENSEMBL:ENSG00000169499 PLEKHA2

HGNC:14336 PLEKHA2

KEGG Gene (Homo sapiens):59339 PLEKHA2

Monarch:59339 PLEKHA2

NCBI Gene:59339 PLEKHA2

OMIM:607773 PLEKHA2

Reference Transcript

RefSeq:NM_021623.1 PLEKHA2

Participates

as a component of

PTPN13:PLEKHA2 [plasma membrane] (Homo sapiens)

Inferred To

plekha2 [plasma membrane] (Xenopus tropicalis)

PLEKHA2 [plasma membrane] (Bos taurus)

PLEKHA2 [plasma membrane] (Canis familiaris)

PLEKHA2 [plasma membrane] (Danio rerio)

PLEKHA2 [plasma membrane] (Rattus norvegicus)

PLEKHA2 [plasma membrane] (Sus scrofa)

Plekha2 [plasma membrane] (Mus musculus)

TAPP2 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_067636.1

OpenTargets

ENSG00000169499

GeneCards

Q9HB19

PRO

Q9HB19

Pharos - Targets

Q9HB19

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q92796 DLG3	2	DLG3 [plasma membrane] (R-HSA-443609) DLG3 [cytosol] (R-HSA-6794232)	0.556	3

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