Reactome | MAGOHB [nucleoplasm]

MAGOHB [nucleoplasm]

Stable Identifier

R-HSA-8867888

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein mago nashi homolog 2, MGN2_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
  - mRNA 3'-end processing (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - Spliced mRNP [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
    - mRNA polyadenylation (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOHB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96A72 MAGOHB

Gene Names

MAGOHB, MAGOH2

Chain

initiator methionine:, chain:2-148

Reference Genes

BioGPS Gene:55110 MAGOHB

COSMIC (genes):MAGOHB MAGOHB

CTD Gene:55110 MAGOHB

dbSNP Gene:55110 MAGOHB

ENSEMBL:ENSG00000111196 MAGOHB

ENSEMBL_homo_sapiens_GENE:ENSG00000111196.10 MAGOHB

HGNC:25504 MAGOHB

KEGG Gene (Homo sapiens):55110 MAGOHB

Monarch:55110 MAGOHB

NCBI Gene:55110 MAGOHB

OMIM:619552 MAGOHB

UCSC:Q96A72 MAGOHB

Reference Transcript

Other Identifiers

11725656_at

11756402_a_at

218894_PM_s_at

218894_s_at

222776_PM_at

222776_at

3444196

3444197

3444198

3444201

3444205

3444207

3444211

3444212

3444213

42517_at

54889_at

55110

7961208

A_24_P330112

GE55705

GO:0000184

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005829

GO:0006397

GO:0006406

GO:0006913

GO:0008380

GO:0016071

GO:0035145

GO:0043025

GO:0043226

GO:0050684

GO:0051028

GO:0071005

GO:0071006

GO:0071013

GO:1990501

GO:2000622

HMNXSV003022861

Hs.104650.0.S2_3p_at

ILMN_1676058

PH_hs_0031492

TC12001225.hg

g8922330_3p_a_at

Participates

as a member of

MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)

Inferred To

Magohb [nucleoplasm] (Rattus norvegicus)

MAGOHB [nucleoplasm] (Bos taurus)

MAGOHB [nucleoplasm] (Canis familiaris)

MAGOHB [nucleoplasm] (Gallus gallus)

MAGOHB [nucleoplasm] (Plasmodium falciparum)

MAGOHB [nucleoplasm] (Sus scrofa)

mag-1 [nucleoplasm] (Caenorhabditis elegans)

mago [nucleoplasm] (Drosophila melanogaster)

mnh1 [nucleoplasm] (Schizosaccharomyces pombe)

magoh [nucleoplasm] (Danio rerio)

magoh [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001306914.1, NP_060518.1

OpenTargets

ENSG00000111196

HPA

ENSG00000111196-MAGOHB

GeneCards

Q96A72

Ensembl

ENSP00000319240, ENST00000320756, ENSG00000111196

PRO

Q96A72

Pharos - Targets

Q96A72

PDB

6ICZ, 6QDV, 5XJC, 5YZG

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3

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