Reactome | L-isoglutamyl polyglycyl-TUBA8 [cytosol]

L-isoglutamyl polyglycyl-TUBA8 [cytosol]

Stable Identifier

R-HSA-8867462

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBA8, Tubulin alpha-8 chain, TBA8_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)
      - Polyglycylated microtubule [cytosol] (Homo sapiens)
        
        Polyglycylated microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglycyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglycyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglycyl alpha tubulin [cytosol] (Homo sapiens)
        
        L-isoglutamyl polyglycyl-TUBA8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NY65 TUBA8

Gene Names

TUBA8, TUBAL2

Chain

chain:1-449, chain:1-448

Reference Genes

BioGPS Gene:51807 TUBA8

COSMIC (genes):TUBA8 TUBA8

CTD Gene:51807 TUBA8

dbSNP Gene:51807 TUBA8

ENSEMBL:ENSG00000183785 TUBA8

ENSEMBL:ENSG00000183785.16 TUBA8

HGNC:12410 TUBA8

KEGG Gene (Homo sapiens):51807 TUBA8

Monarch:51807 TUBA8

NCBI Gene:51807 TUBA8

OMIM:605742 TUBA8

UCSC:Q9NY65 TUBA8

Reference Transcript

Other Identifiers

11755698_a_at

16926932

220069_PM_at

220069_at

3936516

3936517

3936518

3936519

3936521

3936523

3936525

3936527

3936528

3936529

3936534

51807

61935_at

8071147

A_24_P160104

GE55290

GO:0000166

GO:0000226

GO:0000278

GO:0001669

GO:0003824

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007283

GO:0007286

GO:0015630

GO:0016787

GO:0022414

GO:0030154

GO:0031410

GO:0043226

GO:0046872

GO:0048856

HMNXSV003032933

ILMN_1793659

PH_hs_0008290

TC22001452.hg

g9507214_3p_at

Participates

as a candidate of

Polyglycyl alpha tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

AcK-TUBA8 [cytosol]

TUBA8 folding intermediate [cytosol]

TUBA8 unfolded [cytosol]

Polyglutamyl-TUBA8 [cytosol]

TUBA8 [cytosol]

Inferred To

Homologues of L-isoglutamyl polyglycyl-TUBA1C [cytosol] (Dictyostelium discoideum)

Homologues of L-isoglutamyl polyglycyl-TUBA1C [cytosol] (Plasmodium falciparum)

L-isoglutamyl polyglycyl-TUBA8 [cytosol] (Bos taurus)

L-isoglutamyl polyglycyl-TUBA8 [cytosol] (Gallus gallus)

L-isoglutamyl polyglycyl-TUBA8 [cytosol] (Mus musculus)

L-isoglutamyl polyglycyl-TUBA8 [cytosol] (Rattus norvegicus)

L-isoglutamyl polyglycyl-TUBA1C [cytosol] (Dictyostelium discoideum)

L-isoglutamyl polyglycyl-TUBA1C [cytosol] (Plasmodium falciparum)

TUBA8 [cytosol] (Sus scrofa)

Modified Residues

Name

L-isoglutamyl-polyglycine at unknown position

PsiMod Name

L-isoglutamyl-polyglycine

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine.

Cross References

RefSeq

NP_001180343.1, NP_061816.1

OpenTargets

ENSG00000183785

GeneCards

Q9NY65

HPA

ENSG00000183785-TUBA8

Ensembl

ENST00000416740, ENSG00000183785, ENSP00000318575, ENSP00000333326, ENST00000316027, ENST00000330423, ENSP00000412646

PRO

Q9NY65

Pharos - Targets

Q9NY65

Orphanet

19847

HMDB Protein

HMDBP08599

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	3