Reactome | Polyglutamyl-TUBA8 [cytosol]

Polyglutamyl-TUBA8 [cytosol]

Stable Identifier

R-HSA-8867468

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBA8, Tubulin alpha-8 chain, TBA8_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA8 [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA8 [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NY65 TUBA8

Gene Names

TUBA8, TUBAL2

Chain

chain:1-449

Reference Genes

BioGPS Gene:51807 TUBA8

COSMIC (genes):TUBA8 TUBA8

CTD Gene:51807 TUBA8

dbSNP Gene:51807 TUBA8

ENSEMBL:ENSG00000183785 TUBA8

HGNC:12410 TUBA8

KEGG Gene (Homo sapiens):51807 TUBA8

Monarch:51807 TUBA8

NCBI Gene:51807 TUBA8

OMIM:605742 TUBA8

UCSC:Q9NY65 TUBA8

Reference Transcript

Other Identifiers

0005700706

11755698_a_at

16926932

220069_at

3936516

3936517

3936518

3936519

3936521

3936523

3936525

3936527

3936528

3936529

51807

61935_at

8071147

A_24_P160104

GE55290

GO:0000166

GO:0000226

GO:0000278

GO:0003674

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005575

GO:0005622

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007049

GO:0008150

GO:0015630

GO:0043167

GO:0043226

ILMN_1793659

PH_hs_0008290

TC22001452.hg

g9507214_3p_at

Participant Of

hasCandidate

Polyglutamyl alpha tubulin [cytosol]

Other forms of this molecule

AcK-TUBA8 [cytosol]

TUBA8 folding intermediate [cytosol]

TUBA8 unfolded [cytosol]

L-isoglutamyl polyglycyl-TUBA8 [cytosol]

TUBA8 [cytosol]

Inferred To

nda2 [cytosol] (Schizosaccharomyces pombe)

Homologues of Polyglutamyl-TUBA1C [cytosol] (Plasmodium falciparum)

Homologues of Polyglutamyl-TUBA1C [cytosol] (Saccharomyces cerevisiae)

Homologues of Polyglutamyl-TUBA1C [cytosol] (Schizosaccharomyces pombe)

TUB3 [cytosol] (Saccharomyces cerevisiae)

Tuba8 [cytosol] (Mus musculus)

Tuba8 [cytosol] (Rattus norvegicus)

Polyglutamyl-TUBA1C [cytosol] (Plasmodium falciparum)

TUBA8 [cytosol] (Sus scrofa)

tub1 [cytosol] (Schizosaccharomyces pombe)

PEX26 [cytosol] (Canis familiaris)

TUB1 [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_061816.1, NP_001180343.1

Target Pathogen

57c0987dbe737e1cc0a9809f, 57c0987dbe737e1cc0a980a0, 5b354852be737e166372e783, 57c0840cbe737e1cc0a94465

OpenTargets

ENSG00000183785

HPA

ENSG00000183785-TUBA8

GeneCards

Q9NY65

Ensembl

ENSG00000183785, ENSP00000333326, ENSP00000318575, ENST00000316027, ENST00000330423

PRO

Q9NY65

Orphanet

19847

HMDB Protein

HMDBP08599