Reactome | POLE3 [nucleoplasm]

POLE3 [nucleoplasm]

Stable Identifier

R-HSA-8866685

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA polymerase epsilon subunit 3 ecNumber2.7.7.7/ecNumber, DPOE3_HUMAN

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- Base Excision Repair (Homo sapiens)
  - Resolution of Abasic Sites (AP sites) (Homo sapiens)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
      - PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
        
        FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
- DNA Damage Bypass (Homo sapiens)
  - Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
    - PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
      - POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
    - Termination of translesion DNA synthesis (Homo sapiens)
      - POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
      - POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        D-loop extension by DNA polymerases (Homo sapiens)
        
        PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Dual Incision in GG-NER (Homo sapiens)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Dual incision in TC-NER (Homo sapiens)
      - 3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
        
        POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NRF9 POLE3

Gene Names

POLE3, CHRAC17

Chain

initiator methionine:1, chain:2-147

Reference Genes

BioGPS Gene:54107 POLE3

COSMIC (genes):POLE3 POLE3

CTD Gene:54107 POLE3

dbSNP Gene:54107 POLE3

ENSEMBL:ENSG00000148229.13 POLE3

HGNC:13546 POLE3

KEGG Gene (Homo sapiens):54107 POLE3

Monarch:54107 POLE3

NCBI Gene:54107 POLE3

OMIM:607267 POLE3

UCSC:Q9NRF9 POLE3

Reference Transcript

Other Identifiers

0006940551

11755956_x_at

11763496_a_at

11763497_x_at

11763572_s_at

17097495

208828_PM_at

208828_at

3221645

3221647

3221648

3221649

3221650

3221651

3221652

3221653

3221654

3221656

3221658

3221659

3221661

38702_at

54107

8163525

A_23_P135326

GE54666

GO:0000228

GO:0003677

GO:0003887

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0006261

GO:0006272

GO:0006275

GO:0006325

GO:0006334

GO:0006338

GO:0006974

GO:0008622

GO:0008623

GO:0016740

GO:0031490

GO:0031507

GO:0032991

GO:0036211

GO:0043226

GO:0043966

GO:0046982

GO:0065003

GO:0071897

GO:0140097

GO:0140672

HMNXSV003055275

ILMN_1785198

PH_hs_0005994

TC09001503.hg

TC09002753.hg

g13278800_3p_at

g13278800_3p_x_at

Participates

as a component of

DNA polymerase epsilon [nucleoplasm] (Homo sapiens)

Inferred To

POLE3 [nucleoplasm] (Bos taurus)

POLE3 [nucleoplasm] (Caenorhabditis elegans)

POLE3 [nucleoplasm] (Canis familiaris)

POLE3 [nucleoplasm] (Gallus gallus)

POLE3 [nucleoplasm] (Plasmodium falciparum)

POLE3 [nucleoplasm] (Sus scrofa)

pole3 [nucleoplasm] (Dictyostelium discoideum)

pole3 [nucleoplasm] (Xenopus tropicalis)

DPB4 [nucleoplasm] (Saccharomyces cerevisiae)

Chrac-14 [nucleoplasm] (Drosophila melanogaster)

dpb4 [nucleoplasm] (Schizosaccharomyces pombe)

zgc:73351 [nucleoplasm] (Danio rerio)

Pole3 [nucleoplasm] (Mus musculus)

Pole3 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_059139.3, NP_001265184.1

OpenTargets

ENSG00000148229

HPA

ENSG00000148229-POLE3

GeneCards

Q9NRF9

Ensembl

ENSP00000363286, ENSP00000363284, ENST00000374169, ENSG00000148229, ENST00000374171

PRO

Q9NRF9

Pharos - Targets

Q9NRF9

HMDB Protein

HMDBP00966

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