Reactome | pole3 [nucleoplasm]

pole3 [nucleoplasm]

Stable Identifier

R-XTR-8866685

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

POLE3, Q28J93

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle, Mitotic (Xenopus tropicalis)
  - Mitotic G1 phase and G1/S transition (Xenopus tropicalis)
    - G1/S Transition (Xenopus tropicalis)
      - Activation of the pre-replicative complex (Xenopus tropicalis)
        
        DNA polymerase epsilon binds at the origin (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)

DNA Repair (Xenopus tropicalis)

- Base Excision Repair (Xenopus tropicalis)
  - Resolution of Abasic Sites (AP sites) (Xenopus tropicalis)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Xenopus tropicalis)
      - PCNA-Dependent Long Patch Base Excision Repair (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Xenopus tropicalis)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Xenopus tropicalis)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
- DNA Damage Bypass (Xenopus tropicalis)
  - Recognition of DNA damage by PCNA-containing replication complex (Xenopus tropicalis)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Xenopus tropicalis)
      - POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Xenopus tropicalis)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Xenopus tropicalis)
    - Termination of translesion DNA synthesis (Xenopus tropicalis)
      - POLD,POLE binds deISGylated PCNA after TLS (Xenopus tropicalis)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
- Nucleotide Excision Repair (Xenopus tropicalis)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Xenopus tropicalis)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Xenopus tropicalis)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Xenopus tropicalis)
    - Dual incision in TC-NER (Xenopus tropicalis)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Xenopus tropicalis)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)
        
        POLD,POLE [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)
        
        pole3 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q28J93

Gene Names

pole3

Reference Genes

BioGPS Gene:550018 pole3

ENSEMBL:ENSXETG00000034705

KEGG:xtr:550018 pole3

Monarch:550018 pole3

NCBI Gene:550018 pole3

UCSC:Q28J93 pole3

Reference Transcript

Other Identifiers

550018

GO:0005634

GO:0043226

GO:0046982

Participates

as a component of

DNA polymerase epsilon [nucleoplasm] (Xenopus tropicalis)

Inferred From

POLE3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_012825217.1, NP_001017264.1

ENSEMBL

ENSXETP00000084233, ENSXETP00000112896, ENSXETP00000103186, ENSXETT00000120121, ENSXETT00000084382, ENSXETT00000109765

Xenbase

XB-GENE-6455325

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