UBQLNs bind UIM-containing adaptor proteins

Stable Identifier
Reaction [binding]
Homo sapiens
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UBQLN proteins, also known as PLIC (protein linking IAP to cytoskeleton), are a family of four proteins with known roles in targeting ubiquitinated proteins to the proteasome (Mah et al, 2000; Kleijnen et al, 2000; Funakoshi et al, 2002). More recently, UBQLN proteins have been shown to play roles in the regulation of GPCR signaling (N'Diaye and Brown, 2003; Regan-Klapisz et al, 2005; N'Diaye et al, 2008). The ubiquitously expressed UBQLN1 and 2 both interact with UIM-domain containing proteins such as EPS15; the interaction is mediated by the UBQLN C-terminal UbL domain (Regan-Klapisz et al, 2005; N'Diaye et al, 2008). In the case of UBQLN2, interaction with UIM-containing proteins is required for UBQLN2 to negatively regulate clathrin-mediated endocytosis of GPCRs (N'Diaye et al, 2008).

Literature References
PubMed ID Title Journal Year
18199683 The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis

Kajihara, KK, Brown, EJ, Puthenveedu, MA, von Zastrow, M, Wu, P, N'Diaye, EN, Hanyaloglu, AC

Mol. Biol. Cell 2008
14662753 The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gbetagamma

Brown, EJ, N'Diaye, EN

J. Cell Biol. 2003
11076969 Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

Mah, AL, Monteiro, MJ, Smith, MA, Perry, G

J. Cell Biol. 2000
16159959 Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction

Fon, EA, Sorokina, I, Benmerah, A, Voortman, J, Verheesen, P, Urbé, S, de Keizer, P, Roovers, RC, Verkleij, A, Fallon, L, van Bergen en Henegouwen, PM, Regan-Klapisz, E

J. Cell. Sci. 2005
10983987 The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome

Howley, PM, Soccio, RE, Kumar, S, Zhou, P, Kedersha, NL, Gill, G, Kleijnen, MF, Shih, AH

Mol. Cell 2000
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