UBQLNs bind UIM-containing adaptor proteins

Stable Identifier
R-HSA-8866275
Type
Reaction [binding]
Species
Homo sapiens
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UBQLN proteins, also known as PLIC (protein linking IAP to cytoskeleton), are a family of four proteins with known roles in targeting ubiquitinated proteins to the proteasome (Mah et al, 2000; Kleijnen et al, 2000; Funakoshi et al, 2002). More recently, UBQLN proteins have been shown to play roles in the regulation of GPCR signaling (N'Diaye and Brown, 2003; Regan-Klapisz et al, 2005; N'Diaye et al, 2008). The ubiquitously expressed UBQLN1 and 2 both interact with UIM-domain containing proteins such as EPS15; the interaction is mediated by the UBQLN C-terminal UbL domain (Regan-Klapisz et al, 2005; N'Diaye et al, 2008). In the case of UBQLN2, interaction with UIM-containing proteins is required for UBQLN2 to negatively regulate clathrin-mediated endocytosis of GPCRs (N'Diaye et al, 2008).

Literature References
PubMed ID Title Journal Year
14662753 The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gbetagamma

N'Diaye, EN, Brown, EJ

J. Cell Biol. 2003
18199683 The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis

N'Diaye, EN, Hanyaloglu, AC, Kajihara, KK, Puthenveedu, MA, Wu, P, von Zastrow, M, Brown, EJ

Mol. Biol. Cell 2008
11076969 Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

Mah, AL, Perry, G, Smith, MA, Monteiro, MJ

J. Cell Biol. 2000
16159959 Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction

Regan-Klapisz, E, Sorokina, I, Voortman, J, de Keizer, P, Roovers, RC, Verheesen, P, Urbé, S, Fallon, L, Fon, EA, Verkleij, A, Benmerah, A, van Bergen en Henegouwen, PM

J. Cell. Sci. 2005
10983987 The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome

Kleijnen, MF, Shih, AH, Zhou, P, Kumar, S, Soccio, RE, Kedersha, NL, Gill, G, Howley, PM

Mol. Cell 2000
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