Reactome | UBQLNs bind UIM-containing adaptor proteins

UBQLNs bind UIM-containing adaptor proteins

Stable Identifier

R-HSA-8866275

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

UBQLNs bind UIM-containing adaptor proteins

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

UBQLN proteins, also known as PLIC (protein linking IAP to cytoskeleton), are a family of four proteins with known roles in targeting ubiquitinated proteins to the proteasome (Mah et al, 2000; Kleijnen et al, 2000; Funakoshi et al, 2002). More recently, UBQLN proteins have been shown to play roles in the regulation of GPCR signaling (N'Diaye and Brown, 2003; Regan-Klapisz et al, 2005; N'Diaye et al, 2008). The ubiquitously expressed UBQLN1 and 2 both interact with UIM-domain containing proteins such as EPS15; the interaction is mediated by the UBQLN C-terminal UbL domain (Regan-Klapisz et al, 2005; N'Diaye et al, 2008). In the case of UBQLN2, interaction with UIM-containing proteins is required for UBQLN2 to negatively regulate clathrin-mediated endocytosis of GPCRs (N'Diaye et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18199683	The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis N'Diaye, EN, Hanyaloglu, AC, Kajihara, KK, Puthenveedu, MA, Wu, P, von Zastrow, M, Brown, EJ	Mol. Biol. Cell	2008
14662753	The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gbetagamma N'Diaye, EN, Brown, EJ	J. Cell Biol.	2003
11076969	Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation Mah, AL, Perry, G, Smith, MA, Monteiro, MJ	J. Cell Biol.	2000
16159959	Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction Regan-Klapisz, E, Sorokina, I, Voortman, J, de Keizer, P, Roovers, RC, Verheesen, P, Urbé, S, Fallon, L, Fon, EA, Verkleij, A, Benmerah, A, van Bergen en Henegouwen, PM	J. Cell. Sci.	2005
10983987	The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome Kleijnen, MF, Shih, AH, Zhou, P, Kumar, S, Soccio, RE, Kedersha, NL, Gill, G, Howley, PM	Mol. Cell	2000