RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner

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R-HSA-8865711
Type
Reaction [omitted]
Species
Homo sapiens
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Based on studies in mice, Bromodomain and WD repeat-containing protein 1 (BRWD1) is recruited to the Immunoglobulin kappa (IgK) locus through interaction with histone H3 acetylated at lysine residues K9 and K14 and phosphorylated at serine residue S10. ERK is implicated in histone H3 serine S10 phosphorylation at the IGK locus. BRWD1 enhances the recruitment of the RAG1:RAG2 recombinase complex to the IgK locus and positions it at recombination signal sequences within the IgK locus by proper positioning of the nucleosomes, in order for the V(D)J recombination to occur (Mandal et al. 2015). Please note that the listed amino acid residues in mature histone H3 match nascent histone H3 residues K10, K15 and S11, respectively. Amino acid positions in Reactome annotations of modified residues and Reactome systematic names correspond to positions in the nascent protein UniProt sequence.

Literature References
PubMed ID Title Journal Year
26301565 Histone reader BRWD1 targets and restricts recombination to the Igk locus

Mandal, M, Hamel, KM, Maienschein-Cline, M, Tanaka, A, Teng, G, Tuteja, JH, Bunker, JJ, Bahroos, N, Eppig, JJ, Schatz, DG, Clark, MR

Nat. Immunol. 2015
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