RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a Brwd1-dependent manner

Stable Identifier
R-MMU-8865728
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a Brwd1-dependent manner
In mouse small pre-B cells, the recruitment of the Rag1:Rag2 recombinase complex to the proper recombination sites within the Immunoglobulin kappa (Igk) locus is directed and enhanced by Brwd1. Brwd1 associates with the Igk locus through interaction with histone H3 acetylated at lysine residues K9 and K14 and phosphorylated at serine residue S10 (likely by ERK) (Mandal et al. 2015). Please note that the listed amino acid residues in mature histone H3 match nascent histone H3 residues K10, K15 and S11, respectively. Amino acid positions in Reactome annotations of modified residues and Reactome systematic names correspond to positions in the nascent protein UniProt sequence.
Literature References
PubMed ID Title Journal Year
26301565 Histone reader BRWD1 targets and restricts recombination to the Igk locus

Schatz, DG, Hamel, KM, Tuteja, JH, Mandal, M, Bunker, JJ, Bahroos, N, Eppig, JJ, Tanaka, A, Maienschein-Cline, M, Clark, MR, Teng, G

Nat. Immunol. 2015
Participants
Input
Output
This event is regulated
Positively by
Regulator
BRWD1:AcK9,14-p-S10-histone H3.1 [nucleoplasm] (Mus musculus)
Orthologous Events
RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-03-23)
Reviewed
Mandal, M  (2016-05-11)
Created
Orlic-Milacic, M  (2016-03-24)
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