FOXP3 gene expression is stimulated by RUNX1:CBFB

Stable Identifier
R-HSA-8865546
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FOXP3 gene expression is stimulated by RUNX1:CBFB
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Binding of the RUNX1:CBFB complex to the promoter of the FOXP3 gene stimulates FOXP3 transcription (Kitoh et al. 2009).
Literature References
PubMed ID Title Journal Year
19800266 Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells

Yamaguchi, T, Miyachi, Y, Yaguchi, H, Nomura, T, Sakaguchi, S, Naoe, Y, Kitoh, A, Taniuchi, I, Ohkura, N, Tsukada, T, Kitabayashi, I, Ono, M

Immunity 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:FOXP3 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-03-23)
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