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TFAP2A homodimer binds the VEGFA gene promoter
Stable Identifier
R-HSA-8864737
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
TFAP2A homodimer binds the VEGFA gene promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TFAP2A (AP-2 alpha) homodimer can associate with AP-2 response elements in the VEGFA gene promoter (Ruiz et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
14744778
Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells
Bar-Eli, M
,
Song, R
,
Ruiz, M
,
Pettaway, C
,
Stoeltzing, O
,
Ellis, L
Cancer Res.
2004
Participants
Input
TFAP2A homodimer [nucleoplasm]
(Homo sapiens)
VEGFA gene [nucleoplasm]
(Homo sapiens)
Output
TFAP2A homodimer:VEGFA Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
Authored
Orlic-Milacic, M (2016-03-14)
Reviewed
Zarelli, VE (2016-05-04)
Bogachek, MV (2016-05-17)
Dawid, IB (2016-05-04)
Weigel, RJ (2016-05-17)
Created
Orlic-Milacic, M (2016-03-16)
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