KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers

Stable Identifier
R-HSA-8864698
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of AP-2 alpha (TFAP2A) dimer to the KIT gene promoter stimulates KIT transcription. AP-2 beta (TFAP2B) may also stimulate KIT transcription. TFAP2A and KIT levels are frequently reduced in metastatic melanoma (Huang et al. 1998).

Literature References
PubMed ID Title Journal Year
9687504 Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis

Huang, S, Bar-Eli, M, Luca, M, Jean, D, Tainsky, MA

EMBO J. 1998
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TFAP2A,(TFAP2B) homodimers:KIT gene [nucleoplasm] (Homo sapiens)
Active Unit
TFAP2A,(TFAP2B) homodimers [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-16)
Cite Us!