KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers

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R-HSA-8864698
Type
Reaction [omitted]
Species
Homo sapiens
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Binding of AP-2 alpha (TFAP2A) dimer to the KIT gene promoter stimulates KIT transcription. AP-2 beta (TFAP2B) may also stimulate KIT transcription. TFAP2A and KIT levels are frequently reduced in metastatic melanoma (Huang et al. 1998).

Literature References
PubMed ID Title Journal Year
9687504 Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis

Huang, S, Jean, D, Luca, M, Tainsky, MA, Bar-Eli, M

EMBO J. 1998
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