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DCAF11 [nucleoplasm]
Stable Identifier
R-HSA-8863251
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DDB1- and CUL4-associated factor 11, DCA11_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DCAF11 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TEB1 DCAF11
Gene Names
DCAF11, WDR23, GL014, PRO2389
Chain
chain:1-546
Reference Genes
BioGPS Gene:80344 DCAF11
COSMIC (genes):DCAF11 DCAF11
CTD Gene:80344 DCAF11
dbSNP Gene:80344 DCAF11
ENSEMBL:ENSG00000100897 DCAF11
ENSEMBL_homo_sapiens_GENE:ENSG00000100897.18 DCAF11
ENSEMBL_homo_sapiens_GENE:ENSG00000284796.3 DCAF11
HGNC:20258 DCAF11
KEGG Gene (Homo sapiens):80344 DCAF11
Monarch:80344 DCAF11
NCBI Gene:80344 DCAF11
OMIM:613317 DCAF11
UCSC:Q8TEB1 DCAF11
Reference Transcript
RefSeq:NM_025230.4 DCAF11
RefSeq:NM_181357.2 DCAF11
RefSeq:NM_001163484.1 DCAF11
Other Identifiers
11732149_a_at
11732150_x_at
11732151_a_at
11739689_x_at
11739690_a_at
11745179_x_at
16782576
201886_PM_at
201886_at
216389_PM_s_at
216389_s_at
3529548
3529549
3529550
3529551
3529552
3529553
3529554
3529555
3529556
3529559
3529560
3529561
3529562
3529564
3529566
3529567
3529569
3529571
3529573
3529574
3529575
3529578
3529579
3529583
3529585
3529586
3529587
3529588
38449_at
58753_at
7973545
80344
A_23_P117424
A_24_P326957
GE61446
GO:0005515
GO:0005634
GO:0005654
GO:0016567
GO:0030163
GO:0036211
GO:0043161
GO:0043226
GO:0080008
HMNXSV003020663
Hs.283976.1.S1_3p_a_at
ILMN_1765825
ILMN_2389376
PH_hs_0014707
TC14001605.hg
TC14002192.hg
g13489107_3p_at
Participates
as a member of
DCAF protein [nucleoplasm] (Homo sapiens)
Inferred To
Dcaf11 [nucleoplasm]
(Mus musculus)
Dcaf11 [nucleoplasm]
(Rattus norvegicus)
Dmel\CG9945 [nucleoplasm]
(Drosophila melanogaster)
wdr23 [nucleoplasm]
(Dictyostelium discoideum)
DCAF11 [nucleoplasm]
(Bos taurus)
DCAF11 [nucleoplasm]
(Canis familiaris)
DCAF11 [nucleoplasm]
(Sus scrofa)
dcaf11 [nucleoplasm]
(Danio rerio)
dcaf11 [nucleoplasm]
(Xenopus tropicalis)
wdr-23 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_079506.3
,
NP_852002.1
,
NP_001156956.1
OpenTargets
ENSG00000100897
GeneCards
Q8TEB1
HPA
ENSG00000100897-DCAF11
Ensembl
ENST00000646568
,
ENST00000396941
,
ENST00000396936
,
ENSG00000100897
,
ENSP00000415556
,
ENSP00000495416
,
ENSP00000495415
,
ENSP00000380146
,
ENST00000644566
,
ENSP00000493711
,
ENST00000446197
,
ENST00000646524
,
ENSP00000494282
,
ENST00000559115
,
ENST00000642239
,
ENSP00000380142
,
ENSG00000284796
,
ENSP00000452898
PRO
Q8TEB1
Pharos - Targets
Q8TEB1
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.527
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
2
UniProt:O15228 GNPAT
3
GNPAT [cytosol]
(R-HSA-9033129)
GNPAT [peroxisomal membrane]
(R-HSA-1500605)
GNPAT [peroxisomal matrix]
(R-HSA-53413)
0.527
2
UniProt:P11182 DBT
11
DBT [cytosol]
(R-HSA-9714663)
I98M Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865057)
Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-70017)
Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859151)
Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859144)
2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859145)
LipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859167)
DBT [mitochondrial matrix]
(R-HSA-6792584)
P276C Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865046)
S399C Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865036)
K313_Y338del Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865051)
0.527
2
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