Reactome | ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane

ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane

Stable Identifier

R-HSA-8857662

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, plasma membrane

ReviewStatus

5/5

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ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane

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Mammalian cells ubiquitously express three extended-synaptotagmins 1 to 3 (ESYT1-3) which function as Ca2+-regulated endoplasmic reticulum-plasma membrane (ER-PM) tethers. They form homo- and hetero-meric complexes on the ER membrane (heterotrimer shown in this example), are dependent on PI(4,5)P2 in plasma membranes and regulated by cytosolic Ca2+ via the Ca2+-sensing property of ESYT1. An increase in Ca2+ levels contributes to ER-PM tethering, allowing ESYTs to play a putative role in transport of lipids such as glycerophospholipids (GPL) between the two membranes (Giordano et al. 2013, Idevall-Hagren et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26202220	Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering Idevall-Hagren, O, Lü, A, Xie, B, De Camilli, P	EMBO J.	2015
23791178	PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins Giordano, F, Saheki, Y, Idevall-Hagren, O, Colombo, SF, Pirruccello, M, Milosevic, I, Gracheva, EO, Bagriantsev, SN, Borgese, N, De Camilli, P	Cell	2013