ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane

Stable Identifier
R-HSA-8857662
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mammalian cells ubiquitously express three extended-synaptotagmins 1 to 3 (ESYT1-3) which function as Ca2+-regulated endoplasmic reticulum-plasma membrane (ER-PM) tethers. They form homo- and hetero-meric complexes on the ER membrane (heterotrimer shown in this example), are dependent on PI(4,5)P2 in plasma membranes and regulated by cytosolic Ca2+ via the Ca2+-sensing property of ESYT1. An increase in Ca2+ levels contributes to ER-PM tethering, allowing ESYTs to play a putative role in transport of lipids such as glycerophospholipids (GPL) between the two membranes (Giordano et al. 2013, Idevall-Hagren et al. 2015).

Literature References
PubMed ID Title Journal Year
23791178 PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins

Giordano, F, Saheki, Y, Idevall-Hagren, O, Colombo, SF, Pirruccello, M, Milosevic, I, Gracheva, EO, Bagriantsev, SN, Borgese, N, De Camilli, P

Cell 2013
26202220 Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering

Idevall-Hagren, O, Lü, A, Xie, B, De Camilli, P

EMBO J. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipid transporter activity of ESYT1:ESYT2:ESYT3 [endoplasmic reticulum membrane]
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