ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mammalian cells ubiquitously express three extended-synaptotagmins 1 to 3 (ESYT1-3) which function as Ca2+-regulated endoplasmic reticulum-plasma membrane (ER-PM) tethers. They form homo- and hetero-meric complexes on the ER membrane (heterotrimer shown in this example), are dependent on PI(4,5)P2 in plasma membranes and regulated by cytosolic Ca2+ via the Ca2+-sensing property of ESYT1. An increase in Ca2+ levels contributes to ER-PM tethering, allowing ESYTs to play a putative role in transport of lipids such as glycerophospholipids (GPL) between the two membranes (Giordano et al. 2013, Idevall-Hagren et al. 2015).

Literature References
PubMed ID Title Journal Year
26202220 Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering

Xie, B, Idevall-Hagren, O, Lü, A, De Camilli, P

EMBO J. 2015
23791178 PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins

Bagriantsev, SN, Colombo, SF, Gracheva, EO, Milosevic, I, Giordano, F, Idevall-Hagren, O, Saheki, Y, Borgese, N, Pirruccello, M, De Camilli, P

Cell 2013
Catalyst Activity

phospholipid transporter activity of ESYT1:ESYT2:ESYT3 [endoplasmic reticulum membrane]

This event is regulated
Positively by
Orthologous Events
Cite Us!