SALM3 binds LAR-RPTP

Stable Identifier
R-HSA-8855648
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SALM3 interacts with LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) in a transynaptic manner that is dependent upon a splice insert in LAR-RPTPs. This interaction regulates SALM3 dependent presynaptic differentiation (Li et al. 2015). SALM3 knockout mice have fewer excitatory synapsese, but normal plasticity in the hippocampus. However, they are hypoactive, suggesting SALM3 influences locomotion behavior (Li et al. 2015).

Literature References
PubMed ID Title Journal Year
26321637 Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion

Li, Y, Zhang, P, Choi, TY, Park, SK, Park, H, Lee, EJ, Lee, D, Roh, JD, Mah, W, Kim, R, Kim, Y, Kwon, H, Bae, YC, Choi, SY, Craig, AM, Kim, E

Cell Rep 2015
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