Reactome | SALM3 binds LAR-RPTP

SALM3 binds LAR-RPTP

Stable Identifier

R-HSA-8855648

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SALM3 interacts with LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) in a transynaptic manner that is dependent upon a splice insert in LAR-RPTPs. This interaction regulates SALM3 dependent presynaptic differentiation (Li et al. 2015). SALM3 knockout mice have fewer excitatory synapsese, but normal plasticity in the hippocampus. However, they are hypoactive, suggesting SALM3 influences locomotion behavior (Li et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26321637	Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion Li, Y, Zhang, P, Choi, TY, Park, SK, Park, H, Lee, EJ, Lee, D, Roh, JD, Mah, W, Kim, R, Kim, Y, Kwon, H, Bae, YC, Choi, SY, Craig, AM, Kim, E	Cell Rep	2015