SALM3 interacts with LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) in a transynaptic manner that is dependent upon a splice insert in LAR-RPTPs. This interaction regulates SALM3 dependent presynaptic differentiation (Li et al. 2015). SALM3 knockout mice have fewer excitatory synapsese, but normal plasticity in the hippocampus. However, they are hypoactive, suggesting SALM3 influences locomotion behavior (Li et al. 2015).
Choi, SY, Zhang, P, Craig, AM, Kim, Y, Roh, JD, Bae, YC, Lee, D, Park, H, Park, SK, Kim, R, Kwon, H, Kim, E, Li, Y, Choi, TY, Mah, W, Lee, EJ
© 2023 Reactome
